Vascular endothelial growth factor in esophageal cancer

被引：112
作者：
Kleespies, A [1 ]
Guba, M [1 ]
Jauch, KW [1 ]
Bruns, CJ [1 ]
机构：
[1] Univ Munich, Klinikum Grosshadern, Dept Surg, D-81377 Munich, Germany
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2004年 / 87卷 / 02期
关键词：
anti-angiogenic therapy; Barrett's disease; esophagus; lymphangiogenesis; VEGF; VEGF-C;
D O I：
10.1002/jso.20070
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis of many solid malignancies. The influence of angiogenesis and VEGF expression on progression and recurrence of esophageal cancer has been investigated over the last years. This article reviews the prognostic significance of VEGF expression, microvessel density (MVD), and lymphangiogenic factors in squamous cell carcinoma (SCC), Barrett's dysplasia, and adenocarcinoma (AC) of the esophagus, their predictive value for treatment response to chemo-radiotherapy and new anti-angiogenic treatment strategies. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码：95 / 104
页数：10
相关论文
共 95 条
  • [31] 2-I
  • [32] EXPRESSION OF THE FMS-LIKE TYROSINE KINASE-4 GENE BECOMES RESTRICTED TO LYMPHATIC ENDOTHELIUM DURING DEVELOPMENT
    KAIPAINEN, A
    KORHONEN, J
    MUSTONEN, T
    VANHINSBERGH, VWM
    FANG, GH
    DUMONT, D
    BREITMAN, M
    ALITALO, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) : 3566 - 3570
  • [33] KIESER A, 1994, ONCOGENE, V9, P963
  • [34] Kitadai Y, 1998, CLIN CANCER RES, V4, P2195
  • [35] Clinicopathological significance of vascular endothelial growth factor (VEGF)-C in human esophageal squamous cell carcinomas
    Kitadai, Y
    Amioka, T
    Haruma, K
    Tanaka, S
    Yoshihara, M
    Sumii, K
    Matsutani, N
    Yasui, W
    Chayama, K
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2001, 93 (05) : 662 - 666
  • [36] Coexpression of vascular endothelial growth factor and p53 protein in squamous cell carcinoma of the esophagus
    Koide, N
    Nishio, A
    Hiraguri, M
    Hanazaki, K
    Adachi, W
    Amano, J
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2001, 96 (06) : 1733 - 1740
  • [37] Koide N, 1999, HEPATO-GASTROENTEROL, V46, P952
  • [38] VASCULAR ENDOTHELIAL GROWTH-FACTOR VASCULAR-PERMEABILITY FACTOR IS DETECTABLE IN THE SERA OF TUMOR-BEARING MICE AND CANCER-PATIENTS
    KONDO, S
    ASANO, M
    MATSUO, K
    OHMORI, I
    SUZUKI, H
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1994, 1221 (02): : 211 - 214
  • [39] Koukourakis MI, 2001, ANTICANCER RES, V21, P4285
  • [40] Kraft A, 1999, CANCER-AM CANCER SOC, V85, P178
12345678910