Vascular endothelial growth factor in esophageal cancer

被引：112
作者：
Kleespies, A [1 ]
Guba, M [1 ]
Jauch, KW [1 ]
Bruns, CJ [1 ]
机构：
[1] Univ Munich, Klinikum Grosshadern, Dept Surg, D-81377 Munich, Germany
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2004年 / 87卷 / 02期
关键词：
anti-angiogenic therapy; Barrett's disease; esophagus; lymphangiogenesis; VEGF; VEGF-C;
D O I：
10.1002/jso.20070
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis of many solid malignancies. The influence of angiogenesis and VEGF expression on progression and recurrence of esophageal cancer has been investigated over the last years. This article reviews the prognostic significance of VEGF expression, microvessel density (MVD), and lymphangiogenic factors in squamous cell carcinoma (SCC), Barrett's dysplasia, and adenocarcinoma (AC) of the esophagus, their predictive value for treatment response to chemo-radiotherapy and new anti-angiogenic treatment strategies. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码：95 / 104
页数：10
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