Cellular trafficking of nicotinic acetylcholine receptors

被引：24

作者：

St John, Paul A. ^{[1
]}

机构：

[1] Univ Arizona, Coll Med, Dept Cell Biol & Anat, Tucson, AZ 85724 USA

来源：

ACTA PHARMACOLOGICA SINICA | 2009年 / 30卷 / 06期

关键词：

membrane traffic; protein traffic; biosynthesis; endocytosis; endoplasmic reticulum-associated degradation; INDUCED UP-REGULATION; JUNCTION IN-VIVO; ALZHEIMERS-DISEASE; NEUROMUSCULAR-JUNCTION; SURFACE TRAFFICKING; SYNAPTIC PLASTICITY; DEGRADATION RATE; PROTEIN; MEMBRANE; NEURONS;

D O I：

10.1038/aps.2009.76

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nicotinic acetylcholine receptors (nAChRs) play critical roles throughout the body. Precise regulation of the cellular location and availability of nAChRs on neurons and target cells is critical to their proper function. Dynamic, post-translational regulation of nAChRs, particularly control of their movements among the different compartments of cells, is an important aspect of that regulation. A combination of new information and new techniques has the study of nAChR trafficking poised for new breakthroughs.

引用

页码：656 / 662

页数：7

共 55 条

[1] Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo [J].

Akaaboune, M ;

Culican, SM ;

Turney, SG ;

Lichtman, JW .

SCIENCE, 1999, 286 (5439) :503-507

[2] Sphingolipids are necessary for nicotinic acetylcholine receptor export in the early secretory pathway [J].

Baier, C. J. ;

Barrantes, F. J. .

JOURNAL OF NEUROCHEMISTRY, 2007, 101 (04) :1072-1084

[3] Phosphorylation and function of α4β2 receptor [J].

Bermudez, Isabel ;

Moroni, Mirko .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2006, 30 (1-2) :97-98

[4] DENERVATION INCREASES THE DEGRADATION RATE OF ACETYLCHOLINE-RECEPTORS AT ENDPLATES INVIVO AND INVITRO [J].

BEVAN, S ;

STEINBACH, JH .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 336 (MAR) :159-177

[5] Cholesterol depletion activates rapid internalization of submicron-sized acetylcholine receptor domains at the cell membrane [J].

Borroni, V. ;

Baier, C. J. ;

Lang, T. ;

Bonini, I. ;

White, M. M. ;

Garbus, I. ;

Barrantes, F. J. .

MOLECULAR MEMBRANE BIOLOGY, 2007, 24 (01) :1-15

[6] Running to stand still - Ionotropic receptor dynamics at central and peripheral synapses [J].

Bruneau, Emile G. ;

Akaaboune, Mohammed .

MOLECULAR NEUROBIOLOGY, 2006, 34 (02) :137-151

[7] The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo [J].

Bruneau, Emile G. ;

Akaaboune, Mohammed .

DEVELOPMENT, 2006, 133 (22) :4485-4493

[8] Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors [J].

Castillo, M ;

Mulet, J ;

Gutiérrez, LM ;

Ortiz, JA ;

Castelan, F ;

Gerber, S ;

Sala, S ;

Sala, F ;

Criado, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (29) :27062-27068

[9] An acute effect of neuregulin 1β to suppress α7-containing nicotinic acetylcholine receptors in hippocampal interneurons [J].

Chang, Qing ;

Fischbach, Gerald D. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (44) :11295-11303

[10] Rapid upregulation of α7 nicotinic acetylcholine receptors by tyrosine dephosphorylation [J].

Cho, CH ;

Song, WF ;

Leitzell, K ;

Teo, E ;

Meleth, AD ;

Quick, MW ;

Lester, RAJ .

JOURNAL OF NEUROSCIENCE, 2005, 25 (14) :3712-3723

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