Maternal sensitivity, infant limbic structure volume and functional connectivity: a preliminary study

被引:77
作者
Rifkin-Graboi, A. [1 ]
Kong, L. [2 ,3 ]
Sim, L. W. [1 ]
Sanmugam, S. [1 ]
Broekman, B. F. P. [1 ,4 ]
Chen, H. [5 ]
Wong, E. [1 ]
Kwek, K. [6 ]
Saw, S-M [7 ]
Chong, Y-S [1 ,8 ]
Gluckman, P. D. [9 ,10 ]
Fortier, M. V. [11 ]
Pederson, D. [12 ]
Meaney, M. J. [1 ,13 ,14 ]
Qiu, A. [1 ,2 ,3 ]
机构
[1] Singapore Inst Clin Sci, Integrat Neurosci Program, Singapore 117609, Singapore
[2] Natl Univ Singapore, Dept Biomed Engn, Singapore 117548, Singapore
[3] Natl Univ Singapore, Clin Imaging Res Ctr, Singapore 117548, Singapore
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Natl Univ Hlth Syst, Singapore 117595, Singapore
[5] Duke Natl Univ Singapore, KK Womens & Childrens Hosp, Dept Psychol Med, Singapore, Singapore
[6] KK Womens & Childrens Hosp, Dept Maternal Fetal Med, Singapore, Singapore
[7] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Dept Epidemiol, Singapore 117548, Singapore
[8] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Natl Univ Hlth Syst, Singapore 117548, Singapore
[9] Singapore Inst Clin Sci, Human Dev, Singapore, Singapore
[10] Univ Auckland, Liggins Inst, Auckland 1, New Zealand
[11] KK Womens & Childrens Hosp, Dept Diagnost & Intervent Imaging, Singapore, Singapore
[12] Univ Western Ontario, Dept Psychol, London, ON, Canada
[13] McGill Univ, Douglas Mental Hlth Univ Inst, Ludmer Ctr Neuroinformat & Mental Hlth, Dept Neurosci, Montreal, PQ, Canada
[14] McGill Univ, Douglas Mental Hlth Univ Inst, Sackler Program Epigenet & Psychobiol, Montreal, PQ, Canada
来源
TRANSLATIONAL PSYCHIATRY | 2015年 / 5卷
基金
英国医学研究理事会;
关键词
PITUITARY-ADRENAL AXIS; POSTTRAUMATIC-STRESS-DISORDER; CHILD-PARENT ATTACHMENT; EARLY-LIFE STRESS; HIPPOCAMPAL VOLUME; INSECURE ATTACHMENT; ADULT ATTACHMENT; EXTERNALIZING BEHAVIOR; SALIVARY CORTISOL; AMYGDALA VOLUMES;
D O I
10.1038/tp.2015.133
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Mechanisms underlying the profound parental effects on cognitive, emotional and social development in humans remain poorly understood. Studies with nonhuman models suggest variations in parental care affect the limbic system, influential to learning, autobiography and emotional regulation. In some research, nonoptimal care relates to decreases in neurogenesis, although other work suggests early-postnatal social adversity accelerates the maturation of limbic structures associated with emotional learning. We explored whether maternal sensitivity predicts human limbic system development and functional connectivity patterns in a small sample of human infants. When infants were 6 months of age, 20 mother-infant dyads attended a laboratory-based observational session and the infants underwent neuroimaging at the same age. After considering age at imaging, household income and postnatal maternal anxiety, regression analyses demonstrated significant indirect associations between maternal sensitivity and bilateral hippocampal volume at six months, with the majority of associations between sensitivity and the amygdala demonstrating similar indirect, but not significant results. Moreover, functional analyses revealed direct associations between maternal sensitivity and connectivity between the hippocampus and areas important for emotional regulation and socio-emotional functioning. Sensitivity additionally predicted indirect associations between limbic structures and regions related to autobiographical memory. Our volumetric results are consistent with research indicating accelerated limbic development in response to early social adversity, and in combination with our functional results, if replicated in a larger sample, may suggest that subtle, but important, variations in maternal care influence neuroanatomical trajectories important to future cognitive and emotional functioning.
引用
收藏
页码:e668 / e668
页数:12
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