Cognitive/Functional Measures Predict Alzheimer's Disease, Dependent on Hippocampal Volume

被引：15
作者：
Tabatabaei-Jafari, Hossein [1 ]
Shaw, Marnie E. [2 ]
Walsh, Erin [1 ]
Cherbuin, Nicolas [1 ]
机构：
[1] Australian Natl Univ, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia
[2] Australian Natl Univ, Coll Engn & Comp Sci, Canberra, ACT, Australia
来源：
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES | 2020年 / 75卷 / 07期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
Brain/cognitive reserve; Hippocampus; Mild cognitive impairment; MRI; Neuropsychological tests; MILD COGNITIVE IMPAIRMENT; AGE-RELATED-CHANGES; WORKING-MEMORY; OLDER-ADULTS; CONVERSION; DEMENTIA; BRAIN; MARKERS; NETWORK; RESERVE;
D O I：
10.1093/geronb/gbz011
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Objectives: This study aimed to investigate the predictive value of cognitive/functional measures in combination with hippocampal volume (HCV) on the probability of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Methods: The Rey Auditory Verbal Learning Test for immediate memory, Mini-Mental State Examination, a functional assessment for independent daily activities and Alzheimer's Disease Assessment Scale were used as cognitive/functional measures and HCV as neuroimaging measure. Logistic regression and Cox proportional hazard analyses were used to explore the measures' predictive values for AD conversion and time to conversion. Results: The probability of conversion from MCI to AD was associated with cognitive function, but this was moderated by HCV: higher at lower HCV and lower at higher HCV. General cognitive/functional measures were less predictive than immediate memory in predicting time to conversion to AD at small HCVs. Conclusion: Effectiveness of cognitive measures and subtle functional abnormality in predicting conversion from MCI to AD is dependent on HCV, thus combined evaluation should be considered. A combination of HCV and immediate memory appear to perform best in predicting time to conversion.
引用
收藏
页码：1393 / 1402
页数：10
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