The Functions of MicroRNAs: mRNA Decay and Translational Repression

被引：577
作者：
Iwakawa, Hiro-oki [1 ,2 ]
Tomari, Yukihide [1 ,2 ]
机构：
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[2] Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Bunkyo Ku, Tokyo 1130032, Japan
来源：
TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 11期
关键词：
MIRNA-MEDIATED REPRESSION; CAENORHABDITIS-ELEGANS; CCR4-NOT DEADENYLASE; MAMMALIAN MICRORNAS; TARGET RECOGNITION; MOLECULAR INSIGHTS; DECAPPING COMPLEX; PROTEIN-SYNTHESIS; STRUCTURAL BASIS; LET-7; MICRORNA;
D O I：
10.1016/j.tcb.2015.07.011
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs, which regulate complementary mRNAs by inducing translational repression and mRNA decay. Although this dual repression system seems to operate in both animals and plants, genetic and biochemical studies suggest that the mechanism underlying the miRNA-mediated silencing is different in the two kingdoms. Here, we review the recent progress in our understanding of how miRNAs mediate translational repression and mRNA decay, and discuss the contributions of the two silencing modes to the overall silencing effect in both kingdoms.
引用
收藏
页码：651 / 665
页数：15
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