Neutrophil volume distribution width as a new marker in detecting inflammatory bowel disease activation

被引:8
作者
Aydemir, Y. [1 ]
Pinar, A. [2 ]
Hizal, G. [1 ]
Demir, H. [1 ]
Temizel, I. N. Saltik [1 ]
Ozen, H. [1 ]
Akbiyik, F. [2 ]
Yuce, A. [1 ]
机构
[1] Hacettepe Univ, Sch Med, Dept Pediat Gastroenterol Hepatol & Nutr, Ankara, Turkey
[2] Hacettepe Univ, Sch Med, Dept Med Biochem, Ankara, Turkey
关键词
Crohn's disease; neutrophil activation; neutrophil volume distribution width; ulcerative colitis; C-REACTIVE PROTEIN; INTESTINAL INFLAMMATION; CROHNS-DISEASE; ACTIVITY INDEX; POLYMORPHONUCLEAR NEUTROPHILS; ACUTE INFECTION; CYTOKINES; PATHOGENESIS; VALIDATION; SECRETION;
D O I
10.1111/ijlh.12574
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: We sought to investigate the value of neutrophil volume distribution width in detecting inflammatory bowel disease activation. Methods: Patients with infection and accompanying inflammatory disease were excluded. All the patients were diagnosed and classified according to Porto criteria and Paris classification, respectively. Physician global assessment, pediatric Crohn's disease and pediatric ulcerative colitis activity indexes and fecal calprotectin were used to define disease activation. Results: A total of 34 pediatric patients with Inflammatory bowel diseases (IBD) and 29 controls were enrolled in the study. Neutrophil volume distribution width (NVDW) was significantly higher in patients with IBD compared to healthy controls (P < 0.001). An increased NVDW level was observed in IBD patients in activation (22.42 +/- 2.13) compared to those in remission (19.22 +/- 1.63) (P < 0.001). There was no statistically significant difference between IBD patients in remission and healthy controls. The best cutoff of NVDW for prediction of disease activation in Crohn's disease and ulcerative colitis in this series was 20.39 with a sensitivity of 90.9% and a specificity of 75% (AUC: 0.852 CI: 0.698-1.000 P < 0.001) and 19.74 with a sensitivity of 92.9% and a specificity of 90.9% (AUC: 0.961, CI: 0.889-1.000, P < 0.001), respectively. Conclusions: As a quantitative, objective, and sensitive parameter, we believe that the NVDW has a potential to be an additional test detecting disease activation in IBD.
引用
收藏
页码:51 / 57
页数:7
相关论文
共 28 条
  • [1] Neutrophil apoptosis is delayed in patients with inflammatory bowel disease
    Brannigan, AE
    O'Connell, PR
    Hurley, H
    O'Neill, A
    Brady, HR
    Fitzpatrick, JM
    Watson, RWG
    [J]. SHOCK, 2000, 13 (05): : 361 - 366
  • [2] THE PRODUCTION OF CYTOKINES BY POLYMORPHONUCLEAR NEUTROPHILS
    CASSATELLA, MA
    [J]. IMMUNOLOGY TODAY, 1995, 16 (01): : 21 - 26
  • [3] Automated determination of neutrophil VCS parameters in diagnosis and treatment efficacy of neonatal sepsis
    Celik, Istemi H.
    Demirel, Gamze
    Aksoy, Hatice T.
    Erdeve, Omer
    Tuncer, Ece
    Biyikli, Zeynep
    Dilmen, Ugur
    [J]. PEDIATRIC RESEARCH, 2012, 71 (01) : 121 - 125
  • [4] Comparison of neutrophil volume distribution width to C-reactive protein and procalcitonin as a proposed new marker of acute infection
    Charafeddine, Khalil M.
    Youssef, Amira M.
    Mahfouz, Rami A. R.
    Sarieddine, Doja S.
    Daher, Rose T.
    [J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2011, 43 (10) : 777 - 784
  • [5] Chaves F, 2006, ARCH PATHOL LAB MED, V130, P378
  • [6] Escher JC, 2005, J PEDIATR GASTR NUTR, V41, P1
  • [7] Inflammatory bowel disease: Etiology and pathogenesis
    Fiocchi, C
    [J]. GASTROENTEROLOGY, 1998, 115 (01) : 182 - 205
  • [8] The role of neutrophils during intestinal inflammation
    Fournier, B. M.
    Parkos, C. A.
    [J]. MUCOSAL IMMUNOLOGY, 2012, 5 (04) : 354 - 366
  • [9] The Diagnostic Accuracy of Fecal Calprotectin During the Investigation of Suspected Pediatric Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
    Henderson, Paul
    Anderson, Niall H.
    Wilson, David C.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (05) : 637 - 645
  • [10] DEVELOPMENT AND VALIDATION OF A PEDIATRIC CROHNS-DISEASE ACTIVITY INDEX
    HYAMS, JS
    FERRY, GD
    MANDEL, FS
    GRYBOSKI, JD
    KIBORT, PM
    KIRSCHNER, BS
    GRIFFITHS, AM
    KATZ, AJ
    GRAND, RJ
    BOYLE, JT
    MICHENER, WM
    LEVY, JS
    LESSER, ML
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1991, 12 (04) : 439 - 447