Short-course antenatal zidovudine reduces both cervicovaginal human immunodeficiency virus type 1 RNA levels and risk of perinatal transmission

被引：91

作者：

Chuachoowong, R

Shaffer, N

Siriwasin, W

Chaisilwattana, P

Young, NL

Mock, PA

Chearskul, S

Waranawat, N

Chaowanachan, T

Karon, J

Simonds, RJ

Mastro, TD

机构：

[1] Minist Publ Hlth, HIV AIDS Collaborat, Nonthaburi 11000, Thailand

[2] Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok, Thailand

[3] Minist Publ Hlth, Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand

[4] Rajavithi Hosp, Bangkok, Thailand

[5] Ctr Dis Control & Prevent, Atlanta, GA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2000年 / 181卷 / 01期

关键词：

D O I：

10.1086/315179

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus (HIV) levels in cervicovaginal lavage (CVL) and plasma samples were evaluated in relation to perinatal transmission in a randomized placebo-controlled trial of brief antenatal zidovudine treatment, Samples were collected at 38 weeks' gestation from 310 women and more frequently from a subset of 74 women. At 38 weeks, after a 2-week treatment period, CVL HIV-1 was quantifiable in 23% and 52% of samples in the zidovudine and placebo groups, respectively (P < .001), The perinatal transmission rate was 28.7% among women with quantifiable CVL HIV-I and high plasma virus levels (>10,000 copies/mL) and 1% among women without quantifiable CVL HIV-1 and with low plasma virus levels (P < .001). A 1-log increase in plasma HIV-1 increased the transmission odds 1.8 and 6.1 times (95% confidence interval, 0.9-3.5 vs. 2.4-15.4) for women with and without quantifiable CVL HIV-1, respectively (P = .03), CVL HIV-1 is an independent risk factor for perinatal HIV-1 transmission.

引用

页码：99 / 106

页数：8

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