Alterations in gray matter volumes and intrinsic activity in the prefrontal cortex are associated with suicide attempts in patients with bipolar disorder

被引:15
作者
Zhao, Yimeng [1 ,2 ,3 ]
Wang, Lifei [1 ,3 ]
Edmiston, Elliot K. [4 ]
Womer, Fay Y. [5 ]
Jiang, Xiaowei [3 ,6 ]
Wu, Feng [2 ]
Kong, Lingtao [2 ]
Zhou, Yifang [2 ,7 ]
Wang, Fei [2 ,6 ]
Tang, Yanqing [2 ]
Wei, Shengnan [3 ,6 ]
机构
[1] China Med Univ, Dept Psychiat, Shenyang, Liaoning, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Dept Psychiat, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China
[3] China Med Univ, Affiliated Hosp 1, Brain Funct Res Sect, Shenyang, Liaoning, Peoples R China
[4] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
[5] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
[6] China Med Univ, Affiliated Hosp 1, Dept Radiol, 155 Nanjing North St, Shenyang, Liaoning, Peoples R China
[7] China Med Univ, Affiliated Hosp 1, Dept Geriatr Med, Shenyang, Liaoning, Peoples R China
基金
中国国家自然科学基金;
关键词
Bipolar disorder; Suicide attempts; Prefrontal cortex; Gray matter volume; Amplitude of low frequency fluctuations; LINE BRAIN ACTIVITY; MAJOR DEPRESSIVE DISORDER; LOW-FREQUENCY FLUCTUATIONS; FUNCTIONAL CONNECTIVITY; WHITE-MATTER; YOUNG-ADULTS; ORBITOFRONTAL CORTEX; ATTEMPT HISTORY; WORKING-MEMORY; NEURAL SYSTEM;
D O I
10.1016/j.pscychresns.2020.111229
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Bipolar disorder (BD) is associated with increased suicidal behavior. Understanding the neural features of suicide attempts (SA) in patients with BD is critical to preventing suicidal behavior. The prefrontal cortex (PFC) is a key region related to SA. In this study, forty BD patients with a history of SA (BD+SA), 70 BD patients without a history of SA (BD-SA), and 110 individuals in a healthy control (HC) group underwent structural magnetic resonance imaging (MRI) and resting-state functional MRI. We used voxel-based morphometry (VBM) and amplitude of low frequency fluctuations (ALFF) techniques to examine the gray matter volumes (GMVs) and ALFF values in the PFC. Compared with the HC group, both the BD+SA and BD-SA groups had lower GMVs and higher ALFF values in the medial PFC (MPFC), ventral PFC (VPFC), and dorsolateral PFC (DLPFC). The ALFF values in the MPFC, VPFC, and DLPFC in the BD+SA group were significantly higher than those in the BD-SA group. These findings suggest that BD patients with SA have intrinsic activity abnormalities in PFC regions. This provides potentially identifiable neuroimaging markers in BD patients with SA that could be used to increase our understanding of suicidal behavior.
引用
收藏
页数:8
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