Green Synthetic Approach for the Construction of 3,5-Disubstituted 1,2,4-Oxadiazoles and Ataluren Analogues from Dithioesters Using Water

被引：18

作者：

Swarup, Hassan A. ^{[1
]}

Chaithra, Nagaraju ^{[1
]}

Mantelingu, Kempegowda ^{[1
]}

Rangappa, Kanchugarkoppal S. ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysuru 570006, Karnataka, India

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 19期

关键词：

Amidoxime; Ataluren; 3,5-Disubstituted 1,2,4oxadiazole Dithioesters; NaOH; Water; ONE-POT SYNTHESIS; C-H FUNCTIONALIZATION; PHOSPHINE-IMIDAZOLINE LIGANDS; POTENTIAL ANTICANCER AGENTS; PROSTATE-CANCER AGENTS; BIPOLAR HOST MATERIALS; HETERO-FUSED ANALOGS; TANDEM APPROACH; COMPLEMENTARY REGIOSELECTIVITY; DIASTEREOSELECTIVE SYNTHESIS;

D O I：

10.1002/slct.201800886

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An innovative green synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from dithioesters using water as a solvent. This approach becomes more interesting because it undergoes nucleophilic substitution-dehydration-intramolecular cyclization in a single step to give 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields under transition-metal free conditions and allows wide functional group tolerance. This green protocol leads to synthesis of a drug lead molecule, Ataluren and their analogues.

引用

页码：5390 / 5394

页数：5

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