Applications of Gas Chromatography for the Analysis of Tricyclic Antidepressants in Biological Matrices

被引：6
作者：
Manousi, Natalia [1 ]
Samanidou, Victoria F. [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Dept Chem, Lab Analyt Chem, Thessaloniki 54124, Greece
来源：
SEPARATIONS | 2019年 / 6卷 / 02期
关键词：
gas chromatography; tricyclic antidepressants (TCAs); sample treatment; biological fluids; SOLID-PHASE EXTRACTION; LIQUID-LIQUID MICROEXTRACTION; HUMAN-PLASMA; WHOLE-BLOOD; MASS-SPECTROMETRY; ELECTROMEMBRANE EXTRACTION; QUANTITATIVE-DETERMINATION; ANTI-DEPRESSANTS; SOLVENT MICROEXTRACTION; SENSITIVE TECHNIQUE;
D O I：
10.3390/separations6020024
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Tricyclic antidepressant drugs (TCAs) are a main category of antidepressants, which are until today widely used for the treatment of psychological disorders due to their low cost and their high efficiency. Therefore, there is a great demand for method development for the determination of TCAs in biofluids, especially for therapeutic drug monitoring. Gas chromatography (GC) was the first chromatographic technique implemented for this purpose. With the recent development in the field of sample preparation, many novel GC applications have been developed. Herein, we aim to report the recent application of GC for the determination of tricyclic antidepressants in biofluids. Emphasis is given to novel extraction techniques and novel materials used for sample preparation.
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页数：19
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