Aptamer-based therapeutics of the past, present and future: from the perspective of eye-related diseases

被引：37

作者：

Kanwar, Jagat R. ^{[1
]}

Shankaranarayanan, Jayanth Suryanarayanan ^{[1
]}

Gurudevan, Sneha ^{[1
]}

Kanwar, Rupinder K. ^{[1
]}

机构：

[1] Deakin Univ, Fac Hlth, MMR Strateg Res Ctr, Sch Med,NLIMBR, Waurn Ponds, Vic 3217, Australia

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 09期

关键词：

ENDOTHELIAL GROWTH-FACTOR; DIABETIC MACULAR EDEMA; HERPETIC STROMAL KERATITIS; OXYGEN-INDUCED RETINOPATHY; OCULAR DRUG-DELIVERY; AFFINITY RNA LIGANDS; LOCKED NUCLEIC-ACID; ANTISENSE-OLIGONUCLEOTIDES; PEGAPTANIB SODIUM; IN-VIVO;

D O I：

10.1016/j.drudis.2014.02.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aptamers have emerged as a novel and powerful class of biomolecules with an immense untapped potential. The ability to synthesise highly specific aptamers against any molecular target make them a vital cog in the design of effective therapeutics for the future. However, only a minutia of the enormous potential of this dynamic class of molecule has been exploited. Several aptamers have been studied for the treatment of eye-related disorders, and one such strategy has been successful in therapy. This review gives an account of several eye diseases and their regulatory biomolecules where other nucleic acid therapeutics have been attempted with limited success and how aptamers, with their exceptional flexibility to chemical modifications, can overcome those inherent shortcomings.

引用

页码：1309 / 1321

页数：13

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