The Impact of Obesity on Breast Cancer

被引：94

作者：

Argolo, Daniel F. ^{[1
]}

Hudis, Clifford A. ^{[2
,3
]}

Iyengar, Neil M. ^{[2
,3
]}

机构：

[1] CLION CAM Grp, Altino Serbeto de Barros 119,7th Floor, BR-41830907 Salvador, BA, Brazil

[2] Mem Sloan Kettering Canc Ctr, 300 East 66th St,8th Floor, New York, NY 10065 USA

[3] Weill Cornell Med Coll, New York, NY 10065 USA

来源：

CURRENT ONCOLOGY REPORTS | 2018年 / 20卷 / 06期

关键词：

Obesity; Inflammation; Adipose tissue; Insulin; Metabolic syndrome; Breast cancer; BODY-MASS INDEX; CROWN-LIKE STRUCTURES; SEX-STEROID HORMONES; ADIPOSE STROMAL CELLS; NECROSIS-FACTOR-ALPHA; AROMATASE EXPRESSION; CIRCULATING ADIPONECTIN; RECONSTRUCTION ANALYSIS; ENDOCRINE THERAPY; GENE-EXPRESSION;

D O I：

10.1007/s11912-018-0688-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rates of obesity are increasing worldwide and this condition is now recognized as a leading preventable cause of cancer. Several diseases are directly related to obesity, including diabetes, hypertension, atherosclerosis, stroke, musculoskeletal disorders, and a diverse range of malignances-such as breast cancer. Obesity is associated with an increased risk of postmenopausal estrogen receptor-positive breast cancer and worse cancer-related outcomes for all breast tumor subtypes. Several mechanisms have been proposed to contribute to the obesity-cancer link, including high levels of circulating and local estrogens, altered amounts of adipokines (leptin and adiponectin), disrupted insulin/IGF signaling, modifications within the microbiome, and local and systemic effects of inflammation. Here we will review recent advances in our understanding of the complex signaling pathways underlying the obesity-cancer link. An improved understanding of these processes is anticipated to propel novel and effective intervention strategies to reduce the global obesity-cancer burden.

引用

页数：8

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