Background and objectives: Acute promyelocytic leukemia (APL), is a distinct subtype of acute myeloid leukemia (AML) characterized by a tendency to hemorrhage and excellent response to all-trans retinoic acid (ATRA). In this retrospective study, we aimed to determine the incidence, clinical symptoms, toxicities, and outcome of children with APL in our center.Methods: We retrospectively reviewed the medical records of children (age < 18 years) diagnosed with APL in our pediatric hematology department between January 2006-December 2016. Results: Pediatric APL represents 20.5% of AML cases in this cohort. Most of the cases presented as classical M3, albeit hypogranular variant was described in 12% of the cohort. Patients with hypogranular variant APL were differed from classical APL by co-expression of CD2 and CD34. About 3/4 of APL patients had hemorrhagic findings at admission or the induction treatment. Severe bleeding manifested as intracranial hemorrhage was present in three patients and intracranial arterial thrombosis was present in one. Six patients showed side effects of ATRA such as pseudotumor cerebri, differentiation syndrome resulting in dilated cardiomyopathy, and pulmonary infiltrates. Five-year overall survival (OS) and early death rate were found to be 82.5% and 12% respectively. Conclusions: A high frequency (20.5%) of APL was noted among children with AML in this single-center study. The overall mortality rate was 17.5%. Since the induction death rate was 12% and life-threatening bleeding was the primary problem, awareness and urgent treatment are critical factors to reduce early losses.
机构:
Inst Carlos III, Pediat Hematol Oncol Dept, Madrid, SpainHosp Sick Children, Dept Paediat, Div Haematol Oncol, 555 Univ Ave, Toronto, ON, Canada
Lassaletta, Alvaro
Tallman, Martin S.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Leukemia Serv, 1275 York Ave, New York, NY 10021 USAHosp Sick Children, Dept Paediat, Div Haematol Oncol, 555 Univ Ave, Toronto, ON, Canada
机构:
Univ Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8, CanadaUniv Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada
Abla, Oussama
Ribeiro, Raul C.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Int Outreach Program, Memphis, TN 38105 USAUniv Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada
机构:
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021
Calleja E.M.
Warrell R.P.
论文数: 0引用数: 0
h-index: 0
机构:
Genta Incorporated, Berkeley Heights, NJ, 07922Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021
Warrell R.P.
Jr
论文数: 0引用数: 0
h-index: 0
机构:
Genta Incorporated, Berkeley Heights, NJ, 07922Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
Coombs, Catherine C.
DeAngelis, Lisa M.
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Neurol, New York, NY USA
Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
DeAngelis, Lisa M.
Feusner, James H.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp & Res Ctr Oakland, Dept Pediat Hematol Oncol, Oakland, CA USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
Feusner, James H.
Rowe, Jacob M.
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, IsraelMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
Rowe, Jacob M.
Tallman, Martin S.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
机构:
Hannover Med Sch, Hannover, GermanyHannover Med Sch, Hannover, Germany
Creutzig, Ursula
Zimmermann, Martin
论文数: 0引用数: 0
h-index: 0
机构:
Hannover Med Sch, Hannover, GermanyHannover Med Sch, Hannover, Germany
Zimmermann, Martin
论文数: 引用数:
h-index:
机构:
Bourquin, Jean-Pierre
Dworzak, Michael N.
论文数: 0引用数: 0
h-index: 0
机构:
St Anna Childrens Hosp, Dept Pediat, A-1090 Vienna, Austria
Med Univ Vienna, Childrens Canc Res Inst, Vienna, AustriaHannover Med Sch, Hannover, Germany
机构:
Inst Carlos III, Pediat Hematol Oncol Dept, Madrid, SpainHosp Sick Children, Dept Paediat, Div Haematol Oncol, 555 Univ Ave, Toronto, ON, Canada
Lassaletta, Alvaro
Tallman, Martin S.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Leukemia Serv, 1275 York Ave, New York, NY 10021 USAHosp Sick Children, Dept Paediat, Div Haematol Oncol, 555 Univ Ave, Toronto, ON, Canada
机构:
Univ Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8, CanadaUniv Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada
Abla, Oussama
Ribeiro, Raul C.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Int Outreach Program, Memphis, TN 38105 USAUniv Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada
机构:
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021
Calleja E.M.
Warrell R.P.
论文数: 0引用数: 0
h-index: 0
机构:
Genta Incorporated, Berkeley Heights, NJ, 07922Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021
Warrell R.P.
Jr
论文数: 0引用数: 0
h-index: 0
机构:
Genta Incorporated, Berkeley Heights, NJ, 07922Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
Coombs, Catherine C.
DeAngelis, Lisa M.
论文数: 0引用数: 0
h-index: 0
机构:
Weill Cornell Med Coll, Dept Neurol, New York, NY USA
Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
DeAngelis, Lisa M.
Feusner, James H.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp & Res Ctr Oakland, Dept Pediat Hematol Oncol, Oakland, CA USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
Feusner, James H.
Rowe, Jacob M.
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, IsraelMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
Rowe, Jacob M.
Tallman, Martin S.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
Weill Cornell Med Coll, Dept Med, New York, NY USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA
机构:
Hannover Med Sch, Hannover, GermanyHannover Med Sch, Hannover, Germany
Creutzig, Ursula
Zimmermann, Martin
论文数: 0引用数: 0
h-index: 0
机构:
Hannover Med Sch, Hannover, GermanyHannover Med Sch, Hannover, Germany
Zimmermann, Martin
论文数: 引用数:
h-index:
机构:
Bourquin, Jean-Pierre
Dworzak, Michael N.
论文数: 0引用数: 0
h-index: 0
机构:
St Anna Childrens Hosp, Dept Pediat, A-1090 Vienna, Austria
Med Univ Vienna, Childrens Canc Res Inst, Vienna, AustriaHannover Med Sch, Hannover, Germany