Improved Procedure for Preparation of Abiraterone Acetate

被引：11

作者：

Madhra, Mukesh Kumar ^{[1
]}

Sriram, Hari Mohan ^{[1
]}

Inamdar, Murad ^{[1
]}

Sharma, Mukesh Kumar ^{[1
]}

Prasad, Mohan ^{[1
]}

Joseph, Sony ^{[1
]}

机构：

[1] Ranbaxy Res Lab, Div Chem Res, Gurgaon 122001, Haryana, India

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2014年 / 18卷 / 04期

关键词：

PROSTATE-CANCER;

D O I：

10.1021/op500044p

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An improved procedure for the preparation of abiraterone acetate is described. The present process highlights reduced reaction time, isolation with acid-base treatment without involving column chromatography, multiple crystallization and is amenable to large-scale synthesis.

引用

页码：555 / 558

页数：4

共 14 条

[1]

Barrie S. E., 1997, U.S. Patent, Patent No. [5,618,807, 5618807]

[2]

Bury P. S., 2013, U.S. Patent, Patent No. [8,389,714, 8389714]

[3] Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: Synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model [J].

Handratta, VD ;

Vasaitis, TS ;

Njar, VCO ;

Gediya, LK ;

Kataria, R ;

Chopra, P ;

Newman, D ;

Farquhar, R ;

Guo, ZY ;

Qiu, Y ;

Brodie, AMH .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (08) :2972-2984

[4]

Hunt N. J., 2011, U.S. Patent, Patent No. [8,076,474, 8076474]

[5]

Jarman M., 1997, US Patent, Patent No. [5,604, 213, 5604213]

[6] Intramolecular sensitization within steroids:: Excited-state interaction of C-17 α and β carbon-bromine bonds with a C-6 carbonyl group [J].

Li, WS ;

Torun, L ;

Morrison, H .

CANADIAN JOURNAL OF CHEMISTRY, 2003, 81 (06) :660-668

[7]

Marom E., 2014, International Publication Number, Patent No. [WO2014016830A1, 2014016830]

[8] NOVEL STEROIDAL INHIBITORS OF HUMAN CYTOCHROME P450(17-ALPHA) (17-ALPHA-HYDROXYLASE-C-17,C-20-LYASE) - POTENTIAL AGENTS FOR THE TREATMENT OF PROSTATIC-CANCER [J].

POTTER, GA ;

BARRIE, SE ;

JARMAN, M ;

ROWLANDS, MG .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (13) :2463-2471

[9] A convenient, large-scale synthesis of abiraterone acetate [3 beta-acetoxy-17-(3-pyridyl)androsta-5,16-diene], a potential new drug for the treatment of prostate cancer [J].

Potter, GA ;

Hardcastle, IR ;

Jarman, M .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1997, 29 (01) :123-128

[10]

Prez Encabo A., 2013, International Publication Number, Patent No. [WO2013030410A2, 2013030410]

← 1 2 →