ABO Blood Group, Epstein-Barr virus Infection and Prognosis of Patients with Non-metastatic Nasopharyngeal Carcinoma

被引:8
作者
Zhang, Ya-Xiong [1 ,2 ,3 ,4 ]
Kang, Shi-Yang [1 ,2 ,3 ,4 ]
Chen, Gang [1 ,2 ,3 ,4 ]
Fang, Wen-Feng [1 ,2 ,3 ]
Wu, Xuan [1 ,2 ,3 ]
You, Hua-Jing [1 ,2 ,3 ,4 ]
He, Da-Cheng [1 ,2 ,3 ,4 ]
Cao, Ya-Lin [1 ,2 ,3 ,4 ]
Liang, Wen-Hua [1 ,2 ,3 ]
Zhang, Li [1 ,2 ,3 ]
机构
[1] Sun Yat Sen Univ, Dept Med Oncol, Ctr Canc, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Guangzhou 510275, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China
关键词
Nasopharyngeal carcinoma; ABO blood group; Epstein-Barr virus; VcA-IgA; blood lymphocyte; CYTOTOXIC T-CELLS; ADOPTIVE TRANSFER; SERUM ANTIBODIES; RISK; MARKERS; DIAGNOSIS; CANCER; CHINA; IGA;
D O I
10.7314/APJCP.2014.15.17.7459
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: A prior study showed blood type A/AB to be associated with an increased risk of nasopharyngeal carcinoma (NPC) compared to subjects with blood type O. However, the relationship between ABO blood groups and prognosis of NPC patients is still questionable. In addition, whether Epstein-Barr virus (EBV) infection is associated with prognosis of NPC patients with different ABO blood groups is unclear. Materials and Methods: We conducted univariate and multivariable Cox regression analyses based on a consecutive cohort of 1,601 patients to investigate the above issues. Results: There was no significant difference in overall survival (OS) between different ABO blood groups (p=0.629), neither between A vs. non-A blood groups (p=0.895) nor AB vs. non-AB blood group (p=0.309) in univariate analyses and after adjusting for other factors. Interaction tests revealed that high immunoglobulin A against Epstein-Barr virus viral capsid antigen (VcA-IgA) level was associated with a favorable prognosis in male patients with UICC stage II disease who had an A blood type (p=0.008), compared with those with non-A blood type. In addition, male patients with an A blood group with a high blood lymphocyte level showeda tendency towards better survival in UICC stage III (p=0.096). Conclusions: ABO blood group status is not associated with the prognosis of patients with NPC. Additionally, blood group A male NPC patients with high VcA-IgA level or high blood lymphocyte counts might be correlated with a favorable prognosis in UICC stage II or III, respectively.
引用
收藏
页码:7459 / 7465
页数:7
相关论文
共 35 条
[1]   Survey on Converged Data Center Networks with DCB and FCoE: Standards and Protocols [J].
Cai, Yueping ;
Yan, Yao ;
Zhang, Zhenghao ;
Yang, Yuanyuan .
IEEE NETWORK, 2013, 27 (04) :27-32
[2]   Assessing the risk of nasopharyngeal carcinoma on the basis of EBV antibody spectrum [J].
Cheng, WM ;
Chan, KH ;
Chen, HL ;
Luo, RX ;
Ng, SP ;
Luk, W ;
Zheng, BJ ;
Ji, MF ;
Liang, JS ;
Sham, JST ;
Wang, DK ;
Zong, YS ;
Ng, MH .
INTERNATIONAL JOURNAL OF CANCER, 2002, 97 (04) :489-492
[3]   Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men [J].
Chien, YC ;
Chen, JY ;
Liu, MY ;
Yang, HI ;
Hsu, MM ;
Chen, CJ ;
Yang, CS .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (26) :1877-1882
[4]   Adoptive transfer of autologous Epstein-Barr virus-specific cytotoxic T cells for nasopharyngeal carcinoma [J].
Chua, D ;
Huang, J ;
Zheng, BJ ;
Lau, SY ;
Luk, W ;
Kwong, DLW ;
Sham, JST ;
Moss, D ;
Yuen, KY ;
Im, SWK ;
Ng, MH .
INTERNATIONAL JOURNAL OF CANCER, 2001, 94 (01) :73-80
[5]   Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma [J].
Comoli, P ;
De Palma, R ;
Siena, S ;
Nocera, A ;
Basso, S ;
Del Galdo, F ;
Schiavo, R ;
Carminati, O ;
Tagliamacco, A ;
Abbate, GF ;
Locatelli, F ;
Maccario, R ;
Pedrazzoli, P .
ANNALS OF ONCOLOGY, 2004, 15 (01) :113-117
[6]   Laboratory markers of tumor burden in nasopharyngeal carcinoma: A comparison of viral load and serologic tests for Epstein-Barr virus [J].
Fan, HX ;
Nicholls, J ;
Chua, D ;
Chan, KH ;
Sham, J ;
Lee, S ;
Gulley, ML .
INTERNATIONAL JOURNAL OF CANCER, 2004, 112 (06) :1036-1041
[7]   Therapeutic targeting of regulatory T cells enhances tumor-specific CD8+T cell responses in Epstein-Barr virus associated nasopharyngeal carcinoma [J].
Fogg, Mark ;
Murphy, John R. ;
Lorch, Jochen ;
Posner, Marshall ;
Wang, Fred .
VIROLOGY, 2013, 441 (02) :107-113
[8]   Genetic and epigenetic alterations of the blood group ABO gene in oral squamous cell carcinoma [J].
Gao, S ;
Worm, J ;
Guldberg, P ;
Eiberg, H ;
Krogdahl, A ;
Liu, CJ ;
Reibel, J ;
Dabelsteen, E .
INTERNATIONAL JOURNAL OF CANCER, 2004, 109 (02) :230-237
[9]   ABO blood group and incidence of epithelial ovarian cancer [J].
Gates, Margaret A. ;
Wolpin, Brian M. ;
Cramer, Daniel W. ;
Hankinson, Susan E. ;
Tworoger, Shelley S. .
INTERNATIONAL JOURNAL OF CANCER, 2011, 128 (02) :482-486
[10]   Systematic Review on Epstein-Barr Virus (EBV) DNA in Diagnosis of Nasopharyngeal Carcinoma in Asian Populations [J].
Han, Bao-Lin ;
Xu, Xiang-Ying ;
Zhang, Chun-Zhi ;
Wu, Jian-Juan ;
Han, Chun-Feng ;
Wang, Hui ;
Wang, Xuan ;
Wang, Guang-Shun ;
Yang, Shu-Juan ;
Xie, Yao .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (06) :2577-2581