Corneal Collagen Crosslinking Combined with Phototherapeutic Keratectomy and Photorefractive Keratectomy for Corneal Ectasia after Laser in situ Keratomileusis

Purpose: The aim of this study was to analyze the effects of corneal crosslinking (CXL) combined with phototherapeutic keratectomy (PTK) and photorefractive keratectomy (PRK) in halting the progression and improving the visual function of corneal ectasia after laser in situ keratomileusis (LASIK). Methods: PTK-PRK-CXL was performed on 14 eyes of 14 patients who developed corneal ectasia after LASIK. The visual acuity, spherical refraction and cylinder, corneal topography indices, thinnest corneal thickness (TCT), and endothelial cell count were evaluated at baseline and at 1, 3, 6, and 12 months postoperatively. Results: The mean uncorrected visual acuity improved significantly from 0.64 +/- 0.36 logMAR preoperatively to 0.19 +/- 0.12 logMAR at 12 months of follow-up (p < 0.001), while the mean best corrected visual acuity improved from 0.21 +/- 0.14 logMAR at baseline to 0.04 +/- 0.10 logMAR at 12 months postoperatively (p < 0.001). A significant decrease was observed in Kmax and Kmean values from 52.51 +/- 6.74 and 43.55 +/- 3.37 D at baseline to 45.72 +/- 5.18 (p < 0.001) and 40.60 +/- 3.05 D (p < 0.001) at the 1-year follow-up. The mean TCT decreased significantly from 419.07 +/- 36.56 mu m before treatment to 320.93 +/- 39.78 mu m at 12 months of follow-up (p < 0.001), and there was no significant endothelial cell loss (p > 0.05) beyond 6 months after treatment. Conclusion: PTK-PRK-CXL is a promising procedure to halt the progression of post-LASIK keratectasia with significant visual quality improvement. (C) 2018 S. Karger AG, Basel