Parthenolide exerts inhibitory effects on angiogenesis through the downregulation of VEGF/VEGFRs in colorectal cancer

被引：32

作者：

Kim, Se-Lim ^{[1
,2
]}

Lee, Soo-Teik ^{[1
,2
]}

Kieu Thi Thu Trang ^{[1
,2
]}

Kim, Seong Hun ^{[1
,2
]}

Kim, In Hee ^{[1
,2
]}

Lee, Seung Ok ^{[1
,2
]}

Kim, Dae Ghon ^{[1
,2
]}

Kim, Sang-Wook ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Dept Internal Med, Jeonju 561712, Jeonbuk, South Korea

[2] Chonbuk Natl Univ, Res Inst Clin Med, Jeonju 561712, Jeonbuk, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2014年 / 33卷 / 05期

关键词：

parthenolide; colorectal cancer; angiogenesis; human umbilical vein endothelial cells; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; SESQUITERPENE LACTONE PARTHENOLIDE; SUPPRESSES TUMOR-GROWTH; TYROSINE KINASE; INDUCED APOPTOSIS; RECEPTOR SYSTEM; GASTRIC-CANCER; BONE-MARROW; CELL LINES;

D O I：

10.3892/ijmm.2014.1669

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Parthenolide (PT) is responsible for the bioactivities of feverfew (Tanacetum parthenium). Apart from its potent anti-inflammatory effects, this compound has been reported to induce apoptosis in various cancer cells. However, little is known about its role in the process of tumor angiogenesis. In the present study, we investigated the effects and potential mechanisms of action of PT on angiogenesis in human colorectal cancer (CRC). The anti-angiogenic effects of PT were evaluated in cultured human umbilical vein endothelial cells (HUVECs) and in the human CRC cell lines, HT-29, SW620 and HCT116. PT markedly inhibited vascular cell migration and capillary-like structure formation even at a dose which had not effects on cell viability. PT also suppressed the expression of angiogenic biomarker proteins [vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)1 and VEGFR in both the HUVECs and CRC cells. Additionally, PT effectively inhibited tumor neovascularization in a HT-29 xenograft model. These results indicate that PT suppresses angiogenesis by reducing the expression of VEGF and its receptors and may be a viable drug candidate in anti-angiogenesis therapies for human CRC.

引用

页码：1261 / 1267

页数：7

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