Myrmekiosides A and B, novel mono-O-alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge of Myrmekioderma sp.

被引：17

作者：

Aoki, S ^{[1
]}

Higuchi, K ^{[1
]}

Kato, A ^{[1
]}

Murakami, N ^{[1
]}

Kobayashi, M ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 52期

关键词：

glyceroglycolipid; ras transformed cell; marine metabolite; marine sponge;

D O I：

10.1016/S0040-4020(99)00970-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel mono-O-alkyl-diglycosylglycerols named myrmekiosides A (1) and B (2) were isolated from a marine sponge of Myrmekioderma sp. and their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence. Myrmekiosides A (1) and B (2) reversed the phenotype of melanoma H-ras transformed NIH3T3 cells at 5 mu g/ml. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：14865 / 14870

页数：6

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