Targeting the Gut Microbiome for Inflammation and Pain Management in Orthopedic Conditions

被引：4

作者：

Dahshan, Deena ^{[2
]}

Gallagher, Nathaniel ^{[2
]}

Workman, Anthony ^{[2
]}

Perdue, Justin ^{[2
]}

Aikens, Jordan ^{[2
]}

Schmicker, Thomas ^{[1
]}

Shuler, Franklin D. ^{[1
]}

机构：

[1] Marshall Univ, Dept Orthoped Surg, Huntington, WV USA

[2] Joan C Edwards Sch Med, Huntington, WV USA

来源：

ORTHOPEDICS | 2022年 / 45卷 / 05期

关键词：

RANDOMIZED DOUBLE-BLIND; INTESTINAL CALCIUM-ABSORPTION; LACTOBACILLUS-CASEI-SHIROTA; NECROSIS-FACTOR-ALPHA; BONE-MINERAL DENSITY; RHEUMATOID-ARTHRITIS; SHORT-CHAIN; POSTMENOPAUSAL WOMEN; KNEE OSTEOARTHRITIS; PERNA-CANALICULUS;

D O I：

10.3928/01477447-20220608-07

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The human gut microbiome can be altered with probiotics, prebiotics, synbiotics, and anti-inflammatory foods and spices as part of an evidence-based strategy that targets inflammation and pain in common orthopedic conditions. Implementing these strategies avoids adverse effects associated with nonsteroidal anti-inflammatory drugs and minimizes the potential for opioid use. This review focuses exclusively on human trials studying the effects of gut microbiome alterations to address pain and inflammatory markers in common orthopedic conditions: osteoarthritis, rheumatoid arthritis, fractures/osteoporosis, and bone pain associated with chemotherapy. Individualized supplementation strategies can be further explored with the information in this review.

引用

页码：E226 / +

页数：13

共 73 条

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