TITOLO NEUROPEPTIDE NGF MEDIATES NEURO-IMMUNE RESPONSE AND INFLAMMATION THROUGH MAST CELL ACTIVATION

被引：0

作者：

Kritas, S. K. ^{[1
]}

Saggini, A. ^{[2
]}

Cerulli, G. ^{[3
]}

Caraffa, A. ^{[4
]}

Antinolfi, P. ^{[4
]}

Pantalone, A. ^{[5
]}

Frydas, S. ^{[6
]}

Rosati, M. ^{[7
]}

Tei, M. ^{[3
]}

Speziali, A. ^{[3
]}

Saggini, R. ^{[8
]}

Pandolfi, F. ^{[9
]}

Conti, P. ^{[10
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Vet Med, Dept Microbiol & Infect Dis, Thessaloniki 54124, Macedonia, Greece

[2] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[3] Nicolas Fdn, Onlus, Arezzo, Italy

[4] Univ Perugia, Orthopaed Div, I-06100 Perugia, Italy

[5] Univ G dAnnunzio, Orthoped Div, Chieti, Italy

[6] Univ Thessaloniki, Sch Vet Med, Dept Parasitol, GR-54006 Thessaloniki, Macedonia, Greece

[7] Osped Pescara, Gynecol Clin, Pescara, Italy

[8] G Annunzio Univ Chieti Pescara, Fac Med & Surg, Dept Neurosci & Imaging, Chieti, Italy

[9] Univ Cattolica Sacro Cuore, Dept Internal Med, I-00168 Rome, Italy

[10] Univ G dAnnunzio, Sch Med, Div Immunol, Chieti, Italy

来源：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2014年 / 28卷 / 02期

关键词：

mast cells; neuropeptides; nerve growth factor; peptides; inflammation; NERVE GROWTH-FACTOR; SUBSTANCE-P; EXOCYTOSIS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of Fc epsilon RI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).

引用

页码：177 / 181

页数：5

共 15 条

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