Chemosensitivity of resistant colon cancer cell lines to lobaplatin, heptaplatin, and dicycloplatin

被引：7

作者：

Wei, Wen ^{[1
,2
]}

Liu, Zhen ^{[1
]}

Chen, Xi ^{[1
]}

Bi, Feng ^{[1
]}

机构：

[1] West China Hosp, Dept Abdominal Oncol, Ctr Canc, Chengdu, Sichuan, Peoples R China

[2] Sichuan Canc Hosp, Dept Chemotherapy, Chengdu, Sichuan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 2014年 / 52卷 / 08期

基金：

中国国家自然科学基金;

关键词：

chemosensitivity; platinum; drug resistance; colon cancer; COLORECTAL-CANCER; PLATINUM DRUG; ANTITUMOR-ACTIVITY; CLINICAL-TRIAL; PHARMACOKINETICS; CHEMOTHERAPY; ANALOG;

D O I：

10.5414/CP202023

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: Lobaplatin, heptaplatin, and dicycloplatin are three new platinum drugs. The aim of this study is to investigate the chemosensitivity of resistant colon cancer cell lines to these three drugs. Methods: Eight resistant colon cancer cell lines (four oxaliplatin-resistant colon cancer cell lines and four irinotecan-resistant colon cancer cell lines) were cultured in 96-well plates. Lobaplatin, heptaplatin, and dicycloplatin were added in various concentrations. IC50 was determined by MTT assay and the results were confirmed by CCK-8 assay. A cell death detection ELISA assay was performed to quantitate the apoptotic index by detecting the histone-associated DNA fragments generated by the apoptotic cells. Results: Lobaplatin and heptaplatin had an inhibiting effect in all resistant cell lines, dicycloplatin demonstrate only weak antitumor activity in vitro. Conclusions: We confirmed the efficacy of two platinum drugs to oxaliplatin/irinotecan-resistant colon cancer cell lines, suggesting these two drugs could be considered for improving the control of recurrent colon cancer following initial therapy with oxaliplatin and irinotecan.

引用

页码：702 / 708

页数：7

共 22 条

[21] Status of Bi- and Multi-Nuclear Platinum Anticancer Drug Development [J].

Zhang, Jinchao ;

Wang, Liwei ;

Xing, Zhiyong ;

Liu, Dandan ;

Sun, Jing ;

Li, Xiaoliu ;

Zhang, Ying .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2010, 10 (04) :272-282

[22] Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding Study of Platinum Originating from Dicycloplatin, a Novel Antitumor Supramolecule, in Rats and Dogs by ICP-MS [J].

Zhao, Di ;

Zhang, Yongjie ;

Xu, Chunxiang ;

Dong, Can ;

Lin, Hui ;

Zhang, Lingli ;

Li, Cuiyun ;

Ren, Shuangxia ;

Wang, Xin ;

Yang, Shuoye ;

Han, Deen ;

Chen, Xijing .

BIOLOGICAL TRACE ELEMENT RESEARCH, 2012, 148 (02) :203-208

← 1 2 3 →