Design, synthesis and herbicidal activities of novel 4-(1H-pyrazol-1-yl)-6-( alkynyloxy)pyrimidine derivatives as potential pigment biosynthesis inhibitors

被引：24

作者：

Ma, Hong-Ju ^{[1
]}

Zhang, Jian-Hua ^{[1
]}

Xia, Xiang-Dong ^{[1
]}

Xu, Meng-Han ^{[1
]}

Ning, Jun ^{[2
]}

Li, Jian-Hong ^{[1
]}

机构：

[1] Huazhong Agr Univ, Dept Plant Protect, Coll Plant Sci & Technol, Wuhan 430070, Hubei, Peoples R China

[2] Chinese Acad Agr Sci, Key Lab Pesticide Chem & Applicat, Minist Agr, Inst Plant Protect, Beijing 100193, Peoples R China

来源：

PEST MANAGEMENT SCIENCE | 2014年 / 70卷 / 06期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

pigment biosynthesis inhibitors; pyrimidine; chlorophyll; bleaching herbicidal activity; PROTOPORPHYRINOGEN OXIDASE-INHIBITORS; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; ISOXAFLUTOLE; OXYFLUORFEN; MESOTRIONE; MECHANISM; MODE;

D O I：

10.1002/ps.3633

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

BACKGROUNDWith the objective of finding novel valuable herbicidal candidates, a series of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives were synthesised and their herbicide activities were evaluated in vivo. RESULTSThe results showed that many target compounds expressed bleaching activities. Among these, compound 5h showed the best bleaching activity to gramineous weeds, being able to produce the highest inhibition of chlorophyll level in seedlings of Pennisetum alopecuroides L. (IC50 = 3.48mg L-1). Moreover, compound 5h expressed good selective toxicity between gramineous P. alopecuroides L. and broadleaf plant Brassica campestris L. CONCLUSIONSThe present work demonstrates that pyrimidine derivatives containing pyrazole can be used as potential lead compounds for developing novel pigment biosynthesis inhibitors. (c) 2013 Society of Chemical Industry

引用

页码：946 / 952

页数：7

共 27 条

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