Experience with the surgical treatment of adrenal cortical carcinoma

We report on a series of 20 consecutive patients (10 mates, 10 females) with adrenal. cortical. carcinoma (ACC) who were treated by surgery between 1987 and 2001. Aim. The aim of this study was to evaluate the outcome and the role of surgery in the management of this tumour. Result. One patient was at stage I, five patients at stage II, five patients at stage III and nine patients at stage IV of disease. Ten patients suffered from a functioning tumour, whilst ten patients reveated non-functioning tumours. In all patients a transabdominal. approach was performed for the complete resection of the tumour, adjacent organs or metastases. The medium survival after surgical resection, calculated by the Kaplan-Meier method, was 45 months for the overall group, 65 months for patients at stage I or II, 38 months for patients at stage III and 19 months for patients at stage IV of disease. The 5-year survival rate for all patients was 23%, for patients at stage I or II 33%, for patients at stage III 20%, and for patients at stage IV around zero. Conclusion. Radical surgery with a complete resection of the tumour, adjacent organs, solitary metastases and Loco-regional, recurrence wherever possible improves survival, even at advanced stages of disease. (C) 2004 Elsevier Ltd. All rights reserved.