Imaging hallmarks of cancer in living mice

被引：137
作者：
Ellenbroek, Saskia I. J. [1 ]
van Rheenen, Jacco
机构：
[1] Netherlands Hubrecht Inst KNAW, Canc Genom, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands
来源：
NATURE REVIEWS CANCER | 2014年 / 14卷 / 06期
关键词：
IN-VIVO; FLUORESCENCE LIFETIME; BREAST-CANCER; SINGLE-CELL; BONE-MARROW; STEM-CELL; T-CELLS; MULTIPHOTON MICROSCOPY; INTRAVITAL MICROSCOPY; HEMATOPOIETIC STEM;
D O I：
10.1038/nrc3742
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To comprehend the complexity of cancer, the biological characteristics acquired during the initiation and progression of tumours were classified as the 'hallmarks of cancer'. Intravital microscopy techniques have been developed to study individual cells that acquire these crucial traits, by visualizing tissues with cellular or subcellular resolution in living animals. In this Review, we highlight the latest intravital microscopy techniques that have been used in living animals (predominantly mice) to unravel fundamental and dynamic aspects of various hallmarks of cancer. In addition, we discuss the application of intravital microscopy techniques to cancer therapy, as well as limitations and future perspectives for these techniques.
引用
收藏
页码：406 / 418
页数：13
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