Imaging hallmarks of cancer in living mice

被引：137
作者：
Ellenbroek, Saskia I. J. [1 ]
van Rheenen, Jacco
机构：
[1] Netherlands Hubrecht Inst KNAW, Canc Genom, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands
来源：
NATURE REVIEWS CANCER | 2014年 / 14卷 / 06期
关键词：
IN-VIVO; FLUORESCENCE LIFETIME; BREAST-CANCER; SINGLE-CELL; BONE-MARROW; STEM-CELL; T-CELLS; MULTIPHOTON MICROSCOPY; INTRAVITAL MICROSCOPY; HEMATOPOIETIC STEM;
D O I：
10.1038/nrc3742
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To comprehend the complexity of cancer, the biological characteristics acquired during the initiation and progression of tumours were classified as the 'hallmarks of cancer'. Intravital microscopy techniques have been developed to study individual cells that acquire these crucial traits, by visualizing tissues with cellular or subcellular resolution in living animals. In this Review, we highlight the latest intravital microscopy techniques that have been used in living animals (predominantly mice) to unravel fundamental and dynamic aspects of various hallmarks of cancer. In addition, we discuss the application of intravital microscopy techniques to cancer therapy, as well as limitations and future perspectives for these techniques.
引用
收藏
页码：406 / 418
页数：13
相关论文
共 150 条
[1]   Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer [J].
Amornphimoltham, Panomwat ;
Rechache, Kamil ;
Thompson, Jamie ;
Masedunskas, Andrius ;
Leelahavanichkul, Kantima ;
Patel, Vyomesh ;
Molinolo, Alfredo ;
Gutkind, J. Silvio ;
Weigert, Roberto .
CLINICAL CANCER RESEARCH, 2013, 19 (06) :1375-1388
[2]   An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein [J].
Ando, R ;
Hama, H ;
Yamamoto-Hino, M ;
Mizuno, H ;
Miyawaki, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12651-12656
[3]   Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging [J].
Andresen, Volker ;
Alexander, Stephanie ;
Heupel, Wolfgang-Moritz ;
Hirschberg, Markus ;
Hoffman, Robert M. ;
Friedl, Peter .
CURRENT OPINION IN BIOTECHNOLOGY, 2009, 20 (01) :54-62
[4]   Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors [J].
Baluk, P ;
Morikawa, S ;
Haskell, A ;
Mancuso, M ;
McDonald, DM .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (05) :1801-1815
[5]   Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? [J].
Bockhorn, Maximilian ;
Jain, Rakesh K. ;
Munn, Lance L. .
LANCET ONCOLOGY, 2007, 8 (05) :444-448
[6]   Contribution of CXCL12 secretion to invasion of breast cancer cells [J].
Boimel, Pamela J. ;
Smirnova, Tatiana ;
Zhou, Zhen Ni ;
Wyckoff, Jeffrey ;
Park, Haein ;
Coniglio, Salvatore J. ;
Qian, Bin-Zhi ;
Stanley, E. Richard ;
Cox, Dianne ;
Pollard, Jeffrey W. ;
Muller, William J. ;
Condeelis, John ;
Segall, Jeffrey E. .
BREAST CANCER RESEARCH, 2012, 14 (01)
[7]   In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor [J].
Boissonnas, Alexandre ;
Fetler, Luc ;
Zeelenberg, Ingrid S. ;
Hugues, Stphanie ;
Amigorena, Sebastian .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (02) :345-356
[8]   CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network [J].
Boissonnas, Alexandre ;
Licata, Fabrice ;
Poupel, Lucie ;
Jacquelin, Sebastien ;
Fetler, Luc ;
Krumeich, Sophie ;
Thery, Clotilde ;
Amigorena, Sebastian ;
Combadiere, Christophe .
NEOPLASIA, 2013, 15 (01) :85-+
[9]   Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice [J].
Breart, Beatrice ;
Lemaitre, Fabrice ;
Celli, Susanna ;
Bousso, Philippe .
JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (04) :1390-1397
[10]  
Cai D, 2013, NAT METHODS, V10, P540, DOI [10.1038/nmeth.2450, 10.1038/NMETH.2450]
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