The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins

被引：137

作者：

Garavito, RM ^{[1
]}

DeWitt, DL ^{[1
]}

机构：

[1] Michigan State Univ, Dept Biochem, E Lansing, MI 48824 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1999年 / 1441卷 / 2-3期

关键词：

cyclooxygenase; membrane protein; aspirin; prostaglandin biosynthesis;

D O I：

10.1016/S1388-1981(99)00147-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite the marked differences in their physiological roles, the structures and catalytic functions of the cyclooxygenase isozymes COX-1 and -2 are virtually identical. Nevertheless, a handful of amino acid substitutions give rise to subtle differences in ligand binding between the two isoforms. These 'small' alterations of isozyme structure are sufficient to allow the design of new, isoform-selective drugs. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：278 / 287

页数：10

共 31 条

[1] Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1 [J].

Bhattacharyya, DK ;

Lecomte, M ;

Rieke, CJ ;

Garavito, RM ;

Smith, WL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (04) :2179-2184

[2] EPIDERMAL GROWTH FACTOR-LIKE MODULES [J].

CAMPBELL, ID ;

BORK, P .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (03) :385-392

[3]

CHASE M, 1998, WALL ST J 0530

[4] PROSTAGLANDIN-H SYNTHASE [J].

GARAVITO, RM ;

PICOT, D ;

LOLL, PJ .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1994, 4 (04) :529-535

[5] ASPIRIN AND THE RISK OF COLORECTAL-CANCER IN WOMEN [J].

GIOVANNUCCI, E ;

EGAN, KM ;

HUNTER, DJ ;

STAMPFER, MJ ;

COLDITZ, GA ;

WILLETT, WC ;

SPEIZER, FE .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (10) :609-614

[6] The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs [J].

Greig, GM ;

Francis, DA ;

Falgueyret, JP ;

Ouellet, M ;

Percival, MD ;

Roy, P ;

Bayly, C ;

Mancini, JA ;

ONeill, GP .

MOLECULAR PHARMACOLOGY, 1997, 52 (05) :829-838

[7] Role of Val(509) in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents [J].

Guo, QP ;

Wang, LH ;

Ruan, KH ;

Kulmacz, RJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (32) :19134-19139

[8] Prostaglandin synthase 2 [J].

Herschman, HR .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1299 (01) :125-140

[9]

KUJUBU DA, 1991, J BIOL CHEM, V266, P12866

[10] COMPARISON OF HYDROPEROXIDE INITIATOR REQUIREMENTS FOR THE CYCLOOXYGENASE ACTIVITIES OF PROSTAGLANDIN-H SYNTHASE-1 AND SYNTHASE-2 [J].

KULMACZ, RJ ;

WANG, LH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (41) :24019-24023

← 1 2 3 4 →