Visuospatial Working Memory in ADHD Patients, Unaffected Siblings, and Healthy Controls

被引：33
|
作者：
van Ewijk, Hanneke [1 ]
Heslenfeld, Dirk J. [1 ]
Luman, Marjolein
Rommelse, Nanda N. [2 ,3 ]
Hartman, Catharina A. [4 ]
Hoekstra, Pieter
Franke, Barbara [3 ]
Buitelaar, Jan K. [2 ,3 ]
Oosterlaan, Jaap
机构：
[1] Vrije Univ Amsterdam, Dept Psychol, NL-1081 BT Amsterdam, Netherlands
[2] Child & Adolescent Psychiat Univ Ctr Nijmegen, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9700 AB Groningen, Netherlands
来源：
JOURNAL OF ATTENTION DISORDERS | 2014年 / 18卷 / 04期
基金：
美国国家卫生研究院;
关键词：
WM; ADHD; unaffected siblings; development; visuospatial working memory; endophenotype; multilevel analysis; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; EXECUTIVE FUNCTIONS; CHILDREN; ENDOPHENOTYPES; HYPERACTIVITY; RELIABILITY; COMPONENTS; CRITERION; VALIDITY; BOYS;
D O I：
10.1177/1087054713482582
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Objective: The aim of this study was to (a) test the usefulness of visuospatial working memory (VSWM) as an endophenotype for ADHD and (b) study the developmental trajectory of VSWM in ADHD. Method: A total of 110 ADHD patients, 60 unaffected siblings, and 109 controls, aged 8 to 29 years, were assessed on VSWM functioning. Multilevel analyses were carried out to account for the correlation between measurements within families. Results: ADHD patients showed impaired VSWM performance compared with unaffected siblings and controls, with comparable performance between unaffected siblings and controls. Impaired VSWM in ADHD patients was not more pronounced on higher memory loads, signifying executive rather than storage deficits as an underlying mechanism. ADHD patients, unaffected siblings, and controls showed parallel developmental trajectories of VSWM. Conclusion: Current findings question the usefulness of VSWM as a neurocognitive endophenotype for ADHD and provide unique insights into the developmental trajectory of VSWM in ADHD.
引用
收藏
页码：369 / 378
页数：10
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