A case report: acute pancreatitis associated with tacrolimus in kidney transplantation

被引：4
作者：
Xu, Junnan [1 ,2 ,3 ]
Xu, Liang [1 ,2 ,3 ]
Wei, Xing [1 ,2 ]
Li, Xiang [1 ,2 ]
Cai, Ming [1 ,2 ,3 ]
机构：
[1] 309th Hosp Peoples Liberat Army, Organ Transplant Inst Peoples Liberat Army, Beijing, Peoples R China
[2] Beijing Key Lab Immunol Regulatory & Organ Transp, Beijing, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Beijing, Peoples R China
来源：
BMC NEPHROLOGY | 2019年 / 20卷 / 1期
基金：
中国国家自然科学基金;
关键词：
Acute pancreatitis; Tacrolimus; FK506; Kidney transplantation;
D O I：
10.1186/s12882-019-1395-x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
BackgroundTacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation (allo-SCT) over the past 2 decades. Pancreatitis caused by tacrolimus was rarely reported in kidney transplantation previously.Case presentationHere we presented a case of a 45-year-old male who underwent kidney transplantation and received immunosuppressive therapy of tacrolimus, on day +67 after transplantation he developed acute pancreatitis with extremely high blood concentration of tacrolimus. We excluded other possible causes and speculated tacrolimus was the probable inducer of pancreatitis. After tacrolimus was discontinued and alternated with cyclosporine, he gradually recovered and was discharged home with no relapse.ConclusionTacrolimus can be a probable cause of pancreatitis after kidney transplantation. We recommended clinicians to be aware of the possibility of tacrolimus-induced pancreatitis during tacrolimus treatment.
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页数：3
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