A case report: acute pancreatitis associated with tacrolimus in kidney transplantation

被引：5
|
作者：
Xu, Junnan [1 ,2 ,3 ]
Xu, Liang [1 ,2 ,3 ]
Wei, Xing [1 ,2 ]
Li, Xiang [1 ,2 ]
Cai, Ming [1 ,2 ,3 ]
机构：
[1] 309th Hosp Peoples Liberat Army, Organ Transplant Inst Peoples Liberat Army, Beijing, Peoples R China
[2] Beijing Key Lab Immunol Regulatory & Organ Transp, Beijing, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Beijing, Peoples R China
来源：
BMC NEPHROLOGY | 2019年 / 20卷 / 1期
基金：
中国国家自然科学基金;
关键词：
Acute pancreatitis; Tacrolimus; FK506; Kidney transplantation;
D O I：
10.1186/s12882-019-1395-x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
BackgroundTacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation (allo-SCT) over the past 2 decades. Pancreatitis caused by tacrolimus was rarely reported in kidney transplantation previously.Case presentationHere we presented a case of a 45-year-old male who underwent kidney transplantation and received immunosuppressive therapy of tacrolimus, on day +67 after transplantation he developed acute pancreatitis with extremely high blood concentration of tacrolimus. We excluded other possible causes and speculated tacrolimus was the probable inducer of pancreatitis. After tacrolimus was discontinued and alternated with cyclosporine, he gradually recovered and was discharged home with no relapse.ConclusionTacrolimus can be a probable cause of pancreatitis after kidney transplantation. We recommended clinicians to be aware of the possibility of tacrolimus-induced pancreatitis during tacrolimus treatment.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] A case report: acute pancreatitis associated with tacrolimus in kidney transplantation
    Junnan Xu
    Liang Xu
    Xing Wei
    Xiang Li
    Ming Cai
    BMC Nephrology, 20
  • [2] Case Report: Acute Pancreatitis Associated With Tacrolimus in Kidney Transplantation and a Review of the Literature
    Ding, Yixuan
    Qu, Chang
    He, Huan
    Cao, Feng
    Ou, Tongwen
    Li, Fei
    FRONTIERS IN MEDICINE, 2022, 9
  • [3] Acute pancreatitis associated with everolimus after kidney transplantation: a case report
    Fontana, Francesco
    Cappelli, Gianni
    BMC NEPHROLOGY, 2016, 17 : 1 - 4
  • [4] Acute pancreatitis associated with everolimus after kidney transplantation: a case report
    Francesco Fontana
    Gianni Cappelli
    BMC Nephrology, 17
  • [5] MetandienoneCholestatic jaundice, acute kidney injury and acute pancreatitis: case report
    Reactions Weekly, 2011, 1352 (1) : 26 - 26
  • [6] Acute pancreatitis associated with acute aortic dissection: A case report
    Caballero Zamora, Maria Pamela
    Cruz Naval, Marichona
    Lucero Domingo, Felix J. R.
    Balute Gatchalian, Lovell
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 : 252 - 252
  • [7] Trough Tacrolimus Concentrations in the First Week After Kidney Transplantation Are Related to Acute Rejection
    Borobia, Alberto M.
    Romero, Ivan
    Jimenez, Carlos
    Gil, Fernando
    Ramirez, Elena
    De Gracia, Raquel
    Escuin, Fernando
    Gonzalez, Elena
    Carcas Sansuan, Antonio J.
    THERAPEUTIC DRUG MONITORING, 2009, 31 (04) : 436 - 442
  • [8] Optic neuropathy associated with acute pancreatitis: A case report
    Chylova, Hana
    Dubska, Zora
    Kyncl, Martin
    Fus, Martin
    Lestak, Jan
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023, 25 (01)
  • [9] The role of tacrolimus in adult kidney transplantation: a review
    Laskow, DA
    Neylan, JF
    Shapiro, RS
    Pirsch, JD
    Vergne-Marini, PJ
    Tomlanovich, SJ
    CLINICAL TRANSPLANTATION, 1998, 12 (06) : 489 - 503
  • [10] Emergency surgical treatment of complicated acute pancreatitis after kidney transplantation with acute rejection: Case report and literature review
    Klos, Dusan
    Orsag, Jiri
    Lovecek, Martin
    Skalicky, Pavel
    Havlik, Roman
    Zadrazil, Josef
    Neoral, Cestmir
    ANNALS OF MEDICINE AND SURGERY, 2016, 8 : 14 - 17
12345