Methylphenidate enhances acquisition and retention of spatial memory

被引：23
作者：
Carmack, Stephanie A. [1 ]
Block, Carina L. [1 ]
Howell, Kristin K. [1 ]
Anagnostaras, Stephan G. [1 ,2 ]
机构：
[1] Univ Calif San Diego, Dept Psychol, Mol Cognit Lab, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Program Neurosci, La Jolla, CA 92093 USA
来源：
NEUROSCIENCE LETTERS | 2014年 / 567卷
关键词：
Psychostimulant; Fear conditioning; Hippocampus; Mouse; Cognitive enhancement; Water maze; MORRIS WATER MAZE; DEFICIT HYPERACTIVITY DISORDER; WORKING-MEMORY; DOPAMINE; RATS; PERFORMANCE; PSYCHOSTIMULANTS; HIPPOCAMPUS; MODAFINIL; RODENTS;
D O I：
10.1016/j.neulet.2014.03.029
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Psychostimulants containing methylphenidate (MPH) are increasingly being used both on and off-label to enhance learning and memory. Still, almost no studies have investigated MPH's ability to specifically improve spatial or long-term memory. Here we examined the effect of training with 1 or 10 mg/kg MPH on hidden platform learning in the Morris water maze. 10 mg/kg MPH improved memory acquisition and retention, while 1 mg/kg MPH improved memory retention. Taken together with prior evidence that low, clinically relevant, doses of MPH (0.01-1 mg/kg MPH) enhance fear memory we conclude that MPH broadly enhances memory. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：45 / 50
页数：6
相关论文
共 31 条
  • [1] Anagnostaras SG, 2001, HIPPOCAMPUS, V11, P8
  • [2] Automated assessment of Pavlovian conditioned freezing and shock reactivity in mice using the VideoFreeze system
    Anagnostaras, Stephan G.
    Wood, Suzanne C.
    Shuman, Tristan
    Cai, Denise J.
    LeDuc, Arthur D.
    Zurn, Karl R.
    Zurn, J. Brooks
    Sage, Jennifer R.
    Herrera, Gerald M.
    [J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2010, 4
  • [3] Differential Sensitivity to Psychostimulants Across Prefrontal Cognitive Tasks: Differential Involvement of Noradrenergic α1- and α2-Receptors
    Berridge, Craig W.
    Shumsky, Jed S.
    Andrzejewski, Matt E.
    McGaughy, Jill A.
    Spencer, Robert C.
    Devilbiss, David M.
    Waterhouse, Barry D.
    [J]. BIOLOGICAL PSYCHIATRY, 2012, 71 (05) : 467 - 473
  • [4] Reversible hippocampal lesions disrupt water maze performance during both recent and remote memory tests
    Broadbent, NJ
    Squire, LR
    Clark, RE
    [J]. LEARNING & MEMORY, 2006, 13 (02) : 187 - 191
  • [5] Animal model of methylphenidate's long-term memory-enhancing effects
    Carmack, Stephanie A.
    Howell, Kristin K.
    Rasaei, Kleou
    Reas, Emilie T.
    Anagnostaras, Stephan G.
    [J]. LEARNING & MEMORY, 2014, 21 (02) : 82 - 89
  • [6] Amphetamine and extinction of cued fear
    Carmack, Stephanie A.
    Wood, Suzanne C.
    Anagnostaras, Stephan G.
    [J]. NEUROSCIENCE LETTERS, 2010, 468 (01) : 18 - 22
  • [7] Interrogating rodents regarding their object and spatial memory
    Clark, RE
    Martin, SJ
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (05) : 593 - 598
  • [8] Hippocampus and remote spatial memory in rats
    Clark, RE
    Broadbent, NJ
    Squire, LR
    [J]. HIPPOCAMPUS, 2005, 15 (02) : 260 - 272
  • [9] Dopamine Release in Dissociable Striatal Subregions Predicts the Different Effects of Oral Methylphenidate on Reversal Learning and Spatial Working Memory
    Clatworthy, Philip L.
    Lewis, Simon J. G.
    Brichard, Laurent
    Hong, Young T.
    Izquierdo, David
    Clark, Luke
    Cools, Roshan
    Aigbirhio, Franklin I.
    Baron, Jean-Claude
    Fryer, Timothy D.
    Robbins, Trevor W.
    [J]. JOURNAL OF NEUROSCIENCE, 2009, 29 (15) : 4690 - 4696
  • [10] Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol
    Eagle, Dawn M.
    Tufft, Miles R. A.
    Goodchild, Hannah L.
    Robbins, Trevor W.
    [J]. PSYCHOPHARMACOLOGY, 2007, 192 (02) : 193 - 206
1234