Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer

被引：41
作者：
Chen, Ruichuan [1 ]
Yik, Jasper H. N. [2 ]
Lew, Qiao Jing [3 ]
Chao, Sheng-Hao [3 ,4 ]
机构：
[1] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Fujian 361005, Peoples R China
[2] Univ Calif Davis, Med Ctr, Lawrence J Ellison Musculoskeletal Res Ctr, Dept Orthopaed Surg, Sacramento, CA 95817 USA
[3] ASTAR, Bioproc Technol Inst, Express Engn Grp, Singapore 138668, Singapore
[4] Natl Univ Singapore, Dept Microbiol, Singapore 117597, Singapore
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
基金：
中国国家自然科学基金;
关键词：
BROMODOMAIN PROTEIN BRD4; POLYMERASE-II TRANSCRIPTION; HISTONE H3 PHOSPHORYLATION; ESTROGEN-RECEPTOR-ALPHA; BREAST CELL-GROWTH; HUMAN CYCLIN T1; RNA-POLYMERASE; GENE-EXPRESSION; HIV-1; TAT; 7SK SNRNA;
D O I：
10.1155/2014/232870
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation. While Brd4 recruits P-TEFb to promoter-proximal chromatins to activate transcription, HEXIM1 sequesters P-TEFb into an inactive complex containing the 7SK small nuclear RNA. Besides regulating P-TEFb's transcriptional activity, recent evidence demonstrates that both Brd4 and HEXIM1 also play novel roles in cell cycle progression and tumorigenesis. Here we will discuss the current knowledge on Brd4 and HEXIM1 and their implication as novel therapeutic options against cancer.
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页数：11
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