Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer

被引：41

作者：

Chen, Ruichuan ^{[1
]}

Yik, Jasper H. N. ^{[2
]}

Lew, Qiao Jing ^{[3
]}

Chao, Sheng-Hao ^{[3
,4
]}

机构：

[1] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Fujian 361005, Peoples R China

[2] Univ Calif Davis, Med Ctr, Lawrence J Ellison Musculoskeletal Res Ctr, Dept Orthopaed Surg, Sacramento, CA 95817 USA

[3] ASTAR, Bioproc Technol Inst, Express Engn Grp, Singapore 138668, Singapore

[4] Natl Univ Singapore, Dept Microbiol, Singapore 117597, Singapore

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

基金：

中国国家自然科学基金;

关键词：

BROMODOMAIN PROTEIN BRD4; POLYMERASE-II TRANSCRIPTION; HISTONE H3 PHOSPHORYLATION; ESTROGEN-RECEPTOR-ALPHA; BREAST CELL-GROWTH; HUMAN CYCLIN T1; RNA-POLYMERASE; GENE-EXPRESSION; HIV-1; TAT; 7SK SNRNA;

D O I：

10.1155/2014/232870

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation. While Brd4 recruits P-TEFb to promoter-proximal chromatins to activate transcription, HEXIM1 sequesters P-TEFb into an inactive complex containing the 7SK small nuclear RNA. Besides regulating P-TEFb's transcriptional activity, recent evidence demonstrates that both Brd4 and HEXIM1 also play novel roles in cell cycle progression and tumorigenesis. Here we will discuss the current knowledge on Brd4 and HEXIM1 and their implication as novel therapeutic options against cancer.

引用

页数：11

共 50 条

[1] PKC phosphorylates HEXIM1 and regulates P-TEFb activity
Fujinaga, Koh
Barboric, Matjaz
Li, Qintong
Luo, Zeping
Price, David H.
Peterlin, B. Matija
NUCLEIC ACIDS RESEARCH, 2012, 40 (18) : 9160 - 9170
[2] 转录延伸相关因子P-TEFb、HEXIM1与Brd4在小鼠胃腺里的荧光免疫检测
林大河
王琦
冉海莹
丁凤
厦门大学学报(自然科学版), 2014, 53 (03) : 443 - 446
[3] Novel insights into transcriptional elongation: Ubiquitination of HEXIM1 and p-TEFb activity
Kehn-Hall, Kylene
Kashanchi, Fatah
CELL CYCLE, 2009, 8 (16) : 2485 - 2485
[4] Human T-Lymphotropic Virus Type 1 Tax Protein Complexes with P-TEFb and Competes for Brd4 and 7SK snRNP/HEXIM1 Binding
Cho, Won-Kyung
Jang, Moon Kyoo
Huang, Keven
Pise-Masison, Cynthia A.
Brady, John N.
JOURNAL OF VIROLOGY, 2010, 84 (24) : 12801 - 12809
[5] Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR
Sedore, Stanley C.
Byers, Sarah A.
Biglione, Sebastian
Price, Jason P.
Maury, Wendy J.
Price, David H.
NUCLEIC ACIDS RESEARCH, 2007, 35 (13) : 4347 - 4358
[6] Structure and Dynamics of a Stabilized Coiled-Coil Domain in the P-TEFb Regulator Hexim1
Bigalke, Janna M.
Dames, Sonja A.
Blankenfeldt, Wulf
Grzesiek, Stephan
Geyer, Matthias
JOURNAL OF MOLECULAR BIOLOGY, 2011, 414 (05) : 639 - 653
[7] P-TEFb and Brd4: actors of the transcription pause release as therapeutical targets
Furlan, Alessandro
Agbazahou, Florence
Henry, Melanie
Gonzalez-Pisfil, Mariano
Le Nezet, Corentin
Champelovier, Dorian
Fournier, Marie
Vandenbunder, Bernard
Bidaux, Gabriel
Heliot, Laurent
M S-MEDECINE SCIENCES, 2018, 34 (8-9): : 685 - 692
[8] Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
Itzen, Friederike
Greifenberg, Ann Katrin
Boesken, Christian A.
Geyer, Matthias
NUCLEIC ACIDS RESEARCH, 2014, 42 (12) : 7577 - 7587
[9] HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer
Shao, Hengyi
Zhu, Qingwei
Lu, Huasong
Chang, Amanda
Gao, Carol
Zhou, Qiang
Luo, Kunxin
MOLECULAR BIOLOGY OF THE CELL, 2020, 31 (17) : 1867 - 1878
[10] Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription
Barboric, Matjaz
Yik, Jasper H. N.
Czudnochowski, Nadine
Yang, Zhiyuan
Chen, Ruichuan
Contreras, Xavier
Geyer, Matthias
Peterlin, B. Matija
Zhou, Qiang
NUCLEIC ACIDS RESEARCH, 2007, 35 (06) : 2003 - 2012

← 1 2 3 4 5 →