Immunity against fungi

被引：102

作者：

Lionakis, Michail S. ^{[1
]}

Iliev, Iliyan D. ^{[2
]}

Hohl, Tobias M. ^{[3
,4
]}

机构：

[1] NIAID, Fungal Pathogenesis Unit, Lab Clin Infect Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] Weill Cornell Med Coll, Dept Med, Jill Roberts Inst Res IBD, New York, NY USA

[3] Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, New York, NY 10021 USA

[4] Mem Sloan Kettering Canc Ctr, Program Immunol, 1275 York Ave, New York, NY 10021 USA

来源：

JCI INSIGHT | 2017年 / 2卷 / 11期

关键词：

C-TYPE LECTIN; PATTERN-RECOGNITION RECEPTOR; ASPERGILLUS-FUMIGATUS CONIDIA; BETA-GLUCAN RECEPTOR; LONG PENTRAXIN PTX3; CANDIDA-ALBICANS; HOST-DEFENSE; INNATE IMMUNITY; DENDRITIC CELLS; TH17; CELLS;

D O I：

10.1172/jci.insight.93156

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pathogenic fungi cause a wide range of syndromes in immune-competent and immune-compromised individuals, with life-threatening disease primarily seen in humans with HIV/AIDS and in patients receiving immunosuppressive therapies for cancer, autoimmunity, and end-organ failure. The discovery that specific primary immune deficiencies manifest with fungal infections and the development of animal models of mucosal and invasive mycoses have facilitated insight into fungus-specific recognition, signaling, effector pathways, and adaptive immune responses. Progress in deciphering the molecular and cellular basis of immunity against fungi is guiding preclinical studies into vaccine and immune reconstitution strategies for vulnerable patient groups. Furthermore, recent work has begun to address the role of endogenous fungal communities in human health and disease. In this review, we summarize a contemporary understanding of protective immunity against fungi.

引用

页数：17

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