Selective Synthesis of 1-Functionalized-alkyl-1H-indazoles

被引：46

作者：

Hunt, Kevin W. ^{[1
]}

Moreno, David A. ^{[1
]}

Suiter, Nicole ^{[1
]}

Clark, Christopher T. ^{[1
]}

Kim, Ganghyeok ^{[1
]}

机构：

[1] Array BioPharma Inc, Boulder, CO 80301 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 21期

关键词：

INDAZOLE; DERIVATIVES; INHIBITORS; EFFICIENT; DESIGN;

D O I：

10.1021/ol902050m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the selective "N1" alkylation of indazoles is described. Use of alpha-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.

引用

页码：5054 / 5057

页数：4

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