Selective Synthesis of 1-Functionalized-alkyl-1H-indazoles

被引：46
|
作者：
Hunt, Kevin W. [1 ]
Moreno, David A. [1 ]
Suiter, Nicole [1 ]
Clark, Christopher T. [1 ]
Kim, Ganghyeok [1 ]
机构：
[1] Array BioPharma Inc, Boulder, CO 80301 USA
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 21期
关键词：
INDAZOLE; DERIVATIVES; INHIBITORS; EFFICIENT; DESIGN;
D O I：
10.1021/ol902050m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the selective "N1" alkylation of indazoles is described. Use of alpha-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.
引用
收藏
页码：5054 / 5057
页数：4
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