Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer

被引：78

作者：

Mei, ChengHan ^{[1
]}

Zhou, ShunChang ^{[2
]}

Zhu, Lin ^{[1
]}

Ming, JiaXiong ^{[1
]}

Zeng, FanDian ^{[1
]}

Xu, Rong ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pharmacol, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Lab Anim, Wuhan 430030, Peoples R China

来源：

MARINE DRUGS | 2017年 / 15卷 / 02期

基金：

中国国家自然科学基金;

关键词：

fucoxanthin; non-small-cell lung cancer; cell cycle arrest; apoptosis; MARINE CAROTENOID FUCOXANTHIN; CELL-CYCLE ARREST; EDIBLE SEAWEED; UP-REGULATION; IN-VIVO; APOPTOSIS; PATHWAY; P53; INHIBITION; ACTIVATION;

D O I：

10.3390/md15020039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumulating evidence suggests anti-proliferative effects of FX on many cancer cell lines including NSCLCs, but the detailed mechanisms remain unclear. In the present investigation, we confirmed molecular mechanisms and in vivo anti-lung cancer effect of FX at the first time. Flow cytometry, real-time PCR, western blotting and immunohistochemistry revealed that FX arrested cell cycle and induced apoptosis by modulating expression of p53, p21, Fas, PUMA, Bcl-2 and caspase-3/8. These results show that FX is a potent marine drug for human non-small-cell lung cancer treatment.

引用

页数：12

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