The role of cancer-associated fibroblasts in breast cancer pathobiology

被引：0

作者：

Jung, Yoon Yang ^{[1
]}

Kim, Hye Min ^{[1
]}

Koo, Ja Seung ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Pathol, Seoul 120752, South Korea

来源：

HISTOLOGY AND HISTOPATHOLOGY | 2016年 / 31卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Breast cancer; Cancer-associated fibroblast; Tumor microenvironment; EPITHELIAL-MESENCHYMAL TRANSITION; INVASIVE DUCTAL CARCINOMA; STROMAL FIBROBLASTS; TUMOR MICROENVIRONMENT; CAVEOLIN-1; EXPRESSION; PROGNOSTIC-SIGNIFICANCE; ACTIVATION PROTEIN; SIGNALING PATHWAY; OXIDATIVE STRESS; STEM-CELLS;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of the tumor microenvironment (TME) is critical in cancer pathobiology. Of the components of the TME, cancer-associated fibroblasts (CAFs) play a major role. Breast cancer is a typical tumor type, forming abundant tumor stroma, and CAFs are involved in various aspects of breast cancer, including carcinogenesis, tumor progression, invasion, metastasis, inflammation, metabolism, therapy resistance, and prognosis. Various factors, such as growth factors, cytokines, hormones secreted from CAFs, paracrine effects promoted by the extracellular matrix (ECM), and mechanical pressure, are involved in cancer development, and there are various crosstalk and signaling pathways among CAFs, cancer cells, epithelial cells, and the ECM. Recent studies have evaluated the potential of CAFs as therapeutic targets in breast cancer. In this review, we discuss the role of CAFs and their clinical implications.

引用

页码：371 / 378

页数：8

共 91 条

[51] VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization [J].

O'Connell, Joyce T. ;

Sugimoto, Hikaru ;

Cooke, Vesselina G. ;

MacDonald, Brian A. ;

Mehta, Ankit I. ;

LeBleu, Valerie S. ;

Dewar, Rajan ;

Rocha, Rafael M. ;

Brentani, Ricardo R. ;

Resnick, Murray B. ;

Neilson, Eric G. ;

Zeisberg, Michael ;

Kalluri, Raghu .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16002-16007

[52] Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion [J].

Orimo, A ;

Gupta, PB ;

Sgroi, DC ;

Arenzana-Seisdedos, F ;

Delaunay, T ;

Naeem, R ;

Carey, VJ ;

Richardson, AL ;

Weinberg, RA .

CELL, 2005, 121 (03) :335-348

[53] Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts [J].

Park, JE ;

Lenter, MC ;

Zimmermann, RN ;

Garin-Chesa, P ;

Old, LJ ;

Rettig, WJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (51) :36505-36512

[54] Differential expression of cancer-associated fibroblast-related proteins according to molecular subtype and stromal histology in breast cancer [J].

Park, Sung Yeon ;

Kim, Hye Min ;

Koo, Ja Seung .

BREAST CANCER RESEARCH AND TREATMENT, 2015, 149 (03) :727-741

[55] Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect" A transcriptional informatics analysis with validation [J].

Pavlides, Stephanos ;

Tsirigos, Aristotelis ;

Vera, Iset ;

Flomenberg, Neal ;

Frank, Philippe G. ;

Casimiro, Mathew C. ;

Wang, Chenguang ;

Fortina, Paolo ;

Addya, Sankar ;

Pestell, Richard G. ;

Martinez-Outschoorn, Ubaldo E. ;

Sotgia, Federica ;

Lisanti, Michael P. .

CELL CYCLE, 2010, 9 (11) :2201-2219

[56] The reverse Warburg effect Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma [J].

Pavlides, Stephanos ;

Whitaker-Menezes, Diana ;

Castello-Cros, Remedios ;

Flomenberg, Neal ;

Witkiewicz, Agnieszka K. ;

Frank, Philippe G. ;

Casimiro, Mathew C. ;

Wang, Chenguang ;

Fortina, Paolo ;

Addya, Sankar ;

Pestell, Richard G. ;

Martinez-Outschoorn, Ubaldo E. ;

Sotgia, Federica ;

Lisanti, Michael P. .

CELL CYCLE, 2009, 8 (23) :3984-4001

[57] Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma [J].

Petersen, OW ;

Nielsen, HL ;

Gudjonsson, T ;

Villadsen, R ;

Rank, F ;

Niebuhr, E ;

Bissell, MJ ;

Ronnov-Jessen, L .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (02) :391-402

[58] The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin [J].

Pontiggia, Osvaldo ;

Sampayo, Rocio ;

Raffo, Diego ;

Motter, Andrea ;

Xu, Ren ;

Bissell, Mina J. ;

de Kier Joffe, Elisa Bal ;

Simian, Marina .

BREAST CANCER RESEARCH AND TREATMENT, 2012, 133 (02) :459-471

[59] Matrix metalloproteinase-induced epithelial-mesenchymal transition: Tumor progression at Snail's pace [J].

Przybylo, Jennifer A. ;

Radisky, Derek C. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (06) :1082-1088

[60] CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [J].

Qian, Bin-Zhi ;

Li, Jiufeng ;

Zhang, Hui ;

Kitamura, Takanori ;

Zhang, Jinghang ;

Campion, Liam R. ;

Kaiser, Elizabeth A. ;

Snyder, Linda A. ;

Pollard, Jeffrey W. .

NATURE, 2011, 475 (7355) :222-U129

← 1 2 3 4 5 6 7 8 9 10 →