A tale of two trials: selectively replicating herpesviruses for brain tumors

被引:12
作者
Kim, DH [1 ]
机构
[1] Hammersmith Hosp, ICSTM, Imperial Canc Res Fund, Viral & Genet Therapy Programme, London W12 0NN, England
关键词
D O I
10.1038/sj.gt.3301213
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:815 / 816
页数:2
相关论文
共 11 条
[1]   Reovirus therapy of tumors with activated Ras pathway [J].
Coffey, MC ;
Strong, JE ;
Forsyth, PA ;
Lee, PWK .
SCIENCE, 1998, 282 (5392) :1332-1334
[2]   A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy [J].
Freytag, SO ;
Rogulski, KR ;
Paielli, DL ;
Gilbert, JD ;
Kim, JH .
HUMAN GENE THERAPY, 1998, 9 (09) :1323-1333
[3]   ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents [J].
Heise, C ;
SampsonJohannes, A ;
Williams, A ;
McCormick, F ;
VonHoff, DD ;
Kirn, DH .
NATURE MEDICINE, 1997, 3 (06) :639-645
[4]  
KIRN D, 1998, P AN M AM SOC CLIN, V17, pA391
[5]   Replication-selective microbiological agents: fighting cancer with targeted germ warfare [J].
Kirn, DH .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (07) :837-839
[6]  
KIRN DH, 1999, P AN M AM SOC CLIN, V18, P1505
[7]   Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial [J].
Markert, JM ;
Medlock, MD ;
Rabkin, SD ;
Gillespie, GY ;
Todo, T ;
Hunter, WD ;
Palmer, CA ;
Feigenbaum, F ;
Tornatore, C ;
Tufaro, F ;
Martuza, RL .
GENE THERAPY, 2000, 7 (10) :867-874
[8]   ATTENUATED MULTI-MUTATED HERPES-SIMPLEX VIRUS-1 FOR THE TREATMENT OF MALIGNANT GLIOMAS [J].
MINETA, T ;
RABKIN, SD ;
YAZAKI, T ;
HUNTER, WD ;
MARTUZA, RL .
NATURE MEDICINE, 1995, 1 (09) :938-943
[9]  
Pawelek JM, 1997, CANCER RES, V57, P4537
[10]   Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma [J].
Rampling, R ;
Cruickshank, G ;
Papanastassiou, V ;
Nicoll, J ;
Hadley, D ;
Brennan, D ;
Petty, R ;
MacLean, A ;
Harland, J ;
McKie, E ;
Mabbs, R ;
Brown, M .
GENE THERAPY, 2000, 7 (10) :859-866