Fermi level-tuned optics of graphene for attocoulomb-scale quantification of electron transfer at single gold nanoparticles

被引:20
作者
Xia, Qing [1 ]
Chen, Zixuan [1 ]
Xiao, Pengwei [1 ]
Wang, Minxuan [1 ]
Chen, Xueqin [1 ]
Zhang, Jian-Rong [1 ]
Chen, Hong-Yuan [1 ]
Zhu, Jun-Jie [1 ]
机构
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
DETECTION REVEALS; MOLECULES; DIFFUSION; TRANSPORT;
D O I
10.1038/s41467-019-11816-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Measurement of electron transfer at single-molecule level is normally restricted by the detection limit of faraday current, currently in a picoampere to nanoampere range. Here we demonstrate a unique graphene-based electrochemical microscopy technique to make an advance in the detection limit. The optical signal of electron transfer arises from the Fermi level-tuned Rayleigh scattering of graphene, which is further enhanced by immobilized gold nanostars. Owing to the specific response to surface charged carriers, graphene-based electrochemical microscopy enables an attoampere-scale detection limit of faraday current at multiple individual gold nanoelectrodes simultaneously. Using the graphene-based electrochemical microscopy, we show the capability to quantitatively measure the attocoulomb-scale electron transfer in cytochrome c adsorbed at a single nanoelectrode. We anticipate the graphene-based electrochemical microscopy to be a potential electrochemical tool for in situ study of biological electron transfer process in organelles, for example the mitochondrial electron transfer, in consideration of the anti-interference ability to chemicals and organisms.
引用
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页数:10
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