Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon

被引：31
作者：
Brito-Sousa, Jose Diego [1 ,2 ]
Santos, Thalie C. [2 ]
Avalos, Sara [3 ]
Fontecha, Gustavo [3 ]
Melo, Gisely C. [1 ,2 ]
Val, Fernando [1 ,2 ]
Siqueira, Andre M. [4 ]
Alecrim, Graca C. [1 ]
Bassat, Quique [5 ,6 ,7 ,8 ]
Lacerda, Marcus V. G. [1 ,9 ]
Monteiro, Wuelton M. [1 ,2 ]
机构：
[1] Univ Estado Amazonas, Fundacao Med Trop Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil
[2] Univ Estado Amazonas, Escola Super Ciencias Saude, Manaus, Amazonas, Brazil
[3] Univ Nacl Autonoma Honduras, Microbiol Res Inst, Tegucigalpa, Honduras
[4] Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, Brazil
[5] Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain
[6] Ctr Invest Saude Manhica, Maputo, Mozambique
[7] Univ Barcelona, Hosp St Joan Deu, Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain
[8] Univ Barcelona, Hosp St Joan Deu, Pediat Dept, Pediat Infect Dis Unit, Barcelona, Spain
[9] Fundacao Oswaldo Cruz, Inst Pesquisas Leonidas & Maria Deane, Manaus, Amazonas, Brazil
来源：
CLINICAL INFECTIOUS DISEASES | 2019年 / 69卷 / 08期
关键词：
G6PD deficiency; acute renal failure; severe anemia; elimination; primaquine;
D O I：
10.1093/cid/ciz122
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This is an important cause of hospitalization among Plasmodium vivax-infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85.2 cases per 100 000 primaquine users.
引用
收藏
页码：1440 / 1442
页数：3
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