Epithelial-mesenchymal transitions in tumour progression

被引：5525
作者：
Thiery, JP [1 ]
机构：
[1] Inst Curie, CNRS, UMR 144, F-75248 Paris 05, France
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 06期
关键词：
D O I：
10.1038/nrc822
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Without epithelial-mesenchymal transitions, in which polarized epithelial cells are converted into motile cells, multicellular organisms would be incapable of getting past the blastula stage of embryonic development. However, this important developmental programme has a more sinister role in tumour progression. Epithelial-mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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收藏
页码：442 / 454
页数：13
相关论文
共 166 条
[11]   CADHERIN EXPRESSION IN CARCINOMAS - ROLE IN THE FORMATION OF CELL-JUNCTIONS AND THE PREVENTION OF INVASIVENESS [J].
BIRCHMEIER, W ;
BEHRENS, J .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1994, 1198 (01) :11-26
[12]   ESSENTIAL ROLE FOR THE C-MET RECEPTOR IN THE MIGRATION OF MYOGENIC PRECURSOR CELLS INTO THE LIMB BUD [J].
BLADT, F ;
RIETHMACHER, D ;
ISENMANN, S ;
AGUZZI, A ;
BIRCHMEIER, C .
NATURE, 1995, 376 (6543) :768-771
[13]  
BLANCO MJ, IN PRESS ONCOGENE
[14]   Induction of epithelial tubules by growth factor HGF depends on the STAT pathway [J].
Boccaccio, C ;
Andò, M ;
Tamagnone, L ;
Bardelli, A ;
Michieli, P ;
Battistini, C ;
Comoglio, PM .
NATURE, 1998, 391 (6664) :285-288
[15]   IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT [J].
BOTTARO, DP ;
RUBIN, JS ;
FALETTO, DL ;
CHAN, AML ;
KMIECIK, TE ;
VANDEWOUDE, GF ;
AARONSON, SA .
SCIENCE, 1991, 251 (4995) :802-804
[16]   Src and Ras are involved in separate pathways in epithelial cell scattering [J].
Boyer, B ;
Roche, S ;
Denoyelle, M ;
Thiery, JP .
EMBO JOURNAL, 1997, 16 (19) :5904-5913
[17]   Src kinase contributes to the metastatic spread of carcinoma cells [J].
Boyer, B ;
Bourgeois, Y ;
Poupon, MF .
ONCOGENE, 2002, 21 (15) :2347-2356
[18]   Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment [J].
Brabletz, T ;
Jung, A ;
Reu, S ;
Porzner, M ;
Hlubek, F ;
Kunz-Schughart, LA ;
Knuechel, R ;
Kirchner, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10356-10361
[19]   Expression of nuclear β-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas [J].
Brabletz, T ;
Herrmann, K ;
Jung, A ;
Faller, G ;
Kirchner, T .
AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (03) :865-870
[20]   Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. [J].
Braun, S ;
Pantel, K ;
Muller, P ;
Janni, W ;
Hepp, F ;
Kentenich, CRM ;
Gastroph, S ;
Wischnik, A ;
Dimpfl, T ;
Kindermann, G ;
Riethmuller, G ;
Schlimok, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (08) :525-533
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