Copper(II), palladium(II) and platinum(II) complexes with 2,2-thiophen-yl-imidazole: Synthesis, spectroscopic characterization, X-ray crystallographic studies and interactions with calf-thymus DNA

被引：15
作者：
Zanvettor, Nina T. [1 ]
Nakahata, Douglas H. [1 ]
de Paiva, Raphael E. F. [1 ]
Ribeiro, Marcos A. [1 ]
Cuin, Alexandre [2 ]
Corbi, Pedro P. [1 ]
Formiga, Andre L. B. [1 ]
机构：
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP, Brazil
[2] Univ Fed Juiz de Fora, BR-36036330 Juiz De Fora, MG, Brazil
来源：
INORGANICA CHIMICA ACTA | 2016年 / 443卷
基金：
巴西圣保罗研究基金会;
关键词：
2,2-Thiophen-yl-imidazole; Structure elucidation; Square complexes; Trans configuration; DNA interaction; ANTIBACTERIAL ACTIVITY; ANTITUMOR ACTIVITIES; CIRCULAR-DICHROISM; CRYSTAL-STRUCTURES; BASIS-SETS; LIGANDS; DERIVATIVES; IMIDAZOLE; BINDING; DFT;
D O I：
10.1016/j.ica.2016.01.011
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
New Cu(II), Pd(II) and Pt(II) complexes with 2,2-thiophen-yl-imidazole (Thim) were synthesized. Elemental and MS analyses indicate the [MCl2(Thim)(2)] composition. The Cu(II) and Pd(II) complexes had their structures solved by single crystal XRD, where each molecule of the ligand coordinates to the metal by the imine nitrogen of the imidazole group. The free ligand had its structure solved by powder XRD studies. Due to the absence of crystallographic data, the Pt(II) complex was analyzed by solid state NMR and IR spectroscopies. DFT studies were also performed and an analogous structure to the Pd(II) complex is proposed for Pt-Thim. Thim, Cu-Thim and Pd-Thim were evaluated about their DNA interactions by UV-Vis spectroscopy, fluorescence measurements with ethidium bromide, Circular Dichroism and determination of denaturation temperature. The results permitted proposing the interaction of Thim with DNA by hydrogen bonding, while for the complexes a covalent bonding is proposed. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：304 / 315
页数：12
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