The pilocarpine model of epilepsy: what have we learned?

被引：134

作者：

Scorza, Fulvio A. ^{[1
]}

Arida, Ricardo M. ^{[2
]}

Naffah-Mazzacoratti, Maria da Graca ^{[1
]}

Scerni, Debora A. ^{[1
]}

Calderazzo, Lineu ^{[1
]}

Cavalheiro, Esper A. ^{[1
]}

机构：

[1] UNIFESP EPM, Disciplina Neurol Expt, BR-04023900 Sao Paulo, Brazil

[2] UNIFESP EPM, Dept Fisiol, BR-04023900 Sao Paulo, Brazil

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2009年 / 81卷 / 03期

关键词：

hippocampus; pilocarpine; temporal lobe epilepsy; rat; SUDDEN UNEXPECTED DEATH; SPONTANEOUS RECURRENT SEIZURES; PHYSICAL-EXERCISE; RAT HIPPOCAMPUS; PROTEOGLYCAN EXPRESSION; ANTIEPILEPTIC DRUGS; UNEXPLAINED DEATH; ECG ABNORMALITIES; B2; RECEPTORS; RISK-FACTORS;

D O I：

10.1590/S0001-37652009000300003

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.

引用

页码：345 / 365

页数：21

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