Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration

被引：67

作者：

Melli, Giorgia

Jack, Christelene

Lambrinos, George L.

Ringkamp, Mathias

Hoke, Ahmet

机构：

[1] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Dept Neurosurg, Sch Med, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Dept Neurosci, Sch Med, Baltimore, MD 21287 USA

来源：

NEUROBIOLOGY OF DISEASE | 2006年 / 24卷 / 03期

关键词：

paclitaxel; distal axonopathy; axonal degeneration; erythropoietin; detyrosinated tubulin; chemotherapy;

D O I：

10.1016/j.nbd.2006.08.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pactitaxel causes a sensory polyneuropathy with characteristic features of distal axonal degeneration. Although the exact mechanisms underlying distal axonal degeneration are unknown, paclitaxel-induced axonal degeneration has been shown to be associated with an increase in detyrosinated tubulin. Here we show that recombinant human erythropoietin prevents axonal degeneration in sensory neurons in vitro and this effect is associated with downregulation of detyrosinated tubulin. Furthermore, in an animal model of paclitaxel-induced distal sensory polyneuropathy, recombinant human erythropoietin protects against distal axonal degeneration. These findings suggest that recombinant human erythropoietin may be useful as a therapy to prevent paclitaxel-induced sensory polyneuropathy in patients undergoing chemotherapy. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：525 / 530

页数：6