Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration

被引:66
作者
Melli, Giorgia
Jack, Christelene
Lambrinos, George L.
Ringkamp, Mathias
Hoke, Ahmet
机构
[1] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Dept Neurosurg, Sch Med, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Dept Neurosci, Sch Med, Baltimore, MD 21287 USA
关键词
paclitaxel; distal axonopathy; axonal degeneration; erythropoietin; detyrosinated tubulin; chemotherapy;
D O I
10.1016/j.nbd.2006.08.014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Pactitaxel causes a sensory polyneuropathy with characteristic features of distal axonal degeneration. Although the exact mechanisms underlying distal axonal degeneration are unknown, paclitaxel-induced axonal degeneration has been shown to be associated with an increase in detyrosinated tubulin. Here we show that recombinant human erythropoietin prevents axonal degeneration in sensory neurons in vitro and this effect is associated with downregulation of detyrosinated tubulin. Furthermore, in an animal model of paclitaxel-induced distal sensory polyneuropathy, recombinant human erythropoietin protects against distal axonal degeneration. These findings suggest that recombinant human erythropoietin may be useful as a therapy to prevent paclitaxel-induced sensory polyneuropathy in patients undergoing chemotherapy. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:525 / 530
页数:6
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