Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones

被引：24

作者：

Ding, Ling ^{[1
]}

Niu, Kaikai ^{[1
]}

Liu, Yuxiu ^{[1
]}

Wang, Qingmin ^{[1
]}

机构：

[1] Nankai Univ, Coll Chem, Frontiers Sci Ctr New Organ Matter, Res Inst Elementoorgan Chem,State Key Lab Element, Tianjin 300071, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2022年 / 33卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Electro-reductive; C-H cyanoalkylation; Reductant-free; Quinoxalin-2(1H)-ones; Ring-opening; CYCLOBUTANONE O-BENZOYLOXIMES; RING-CLEAVAGE; OXIME ESTERS; ALKYLATION;

D O I：

10.1016/j.cclet.2021.12.053

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report a practical electro-reductive protocol for the direct C-H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

引用

页码：4057 / 4060

页数：4

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