Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions

被引：14

作者：

Valero, Megane ^{[1
]}

Mishra, Anurag ^{[1
]}

Blass, Jennifer ^{[1
]}

Weck, Remo ^{[1
]}

Derdau, Volker ^{[1
]}

机构：

[1] Sanofi Aventis Deutschland GmbH, Integrated Drug Discovery, Isotope Chem, Ind Pk Hochst, Frankfurt, Germany

来源：

CHEMISTRYOPEN | 2019年 / 8卷 / 09期

基金：

欧盟地平线“2020”;

关键词：

hydrogen isotope exchange; deuterium; iridium catalysis; C-H functionalization; homogeneous catalysis; IN-VITRO METABOLISM; C-H; DEUTERIUM-EXCHANGE; DRUG DISCOVERY; CRABTREES CATALYST; LABELED COMPOUNDS; COMPLEXES; TRITIUM; FUNCTIONALIZATION; ACTIVATION;

D O I：

10.1002/open.201900204

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1-6) which will help us to understand and optimize the approaches of either high selectivity or maximum deuterium incorporation. We have demonstrated that the temperature window for these studied iridium(I) catalysts is surprisingly very broad. This principle was further proven in some HIE reactions on complex drug molecules.

引用

页码：1183 / 1189

页数：7

共 82 条

[1] Recent applications of C-H functionalization in complex natural product synthesis [J].