A micellar liquid chromatographic method for quality control of pharmaceutical preparations containing tricyclic antidepressants

被引:13
作者
Bermúdez-Saldaña, JM [1 ]
Quiñones-Torrelo, C [1 ]
Sagrado, S [1 ]
Medina-Hernández, MJ [1 ]
Villanueva-Camañas, RM [1 ]
机构
[1] Univ Valencia, Dept Quim Analit, E-46100 Valencia, Spain
关键词
column liquid chromatography; micellar liquid chromatography; tricyclic antidepressants; pharmaceutical preparations;
D O I
10.1007/BF02491936
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Micellar liquid chromatography methods for quality control of pharmaceutical preparations (capsules, pills, tablets, injections) containing the tricyclic antidepressants amineptine, amitriptiline, clomipramine, doxepin, imipramine, melitracen and nortriptyline alone or together with other CNS drugs like diazepam, medazepam and perphenazine are described. The methods using micellar solutions of cetyltrimethylammonium bromide as mobile phases and UV detection are rapid and reproducible. Due to the versatility of interactions in micellar liquid chromatography, it is possible determine highly hydrophobic compounds such as TCAs in a short time using mobile phases containing low organic solvent concentrations and usual flow rates, in contrast with the RP-HPLC methods proposed for these compounds. Samples preparation only requires solution and adequate dilution with the mobile phase before injection into the chromatographic system.
引用
收藏
页码:299 / 306
页数:8
相关论文
共 27 条
[1]  
AMSTRONG DW, 1981, ANAL CHEM, V53, P1662
[2]  
[Anonymous], 1990, COMPREHENSIVE MED CH
[3]   MODEL FOR MICELLAR EFFECTS ON LIQUID-CHROMATOGRAPHY CAPACITY FACTORS AND FOR DETERMINATION OF MICELLE SOLUTE EQUILIBRIUM-CONSTANTS [J].
ARUNYANART, M ;
LOVE, LJC .
ANALYTICAL CHEMISTRY, 1984, 56 (09) :1557-1561
[4]  
Bonet-Domingo E., 1992, ANALYST, V117, P843
[5]   DETERMINATION OF AMINO-ACIDS BY MICELLAR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND PRE-COLUMN DERIVATIZATION WITH O-PHTHALALDEHYDE AND N-ACETYL-L-CYSTEINE [J].
CATALAICARDO, M ;
MEDINAHERNANDEZ, MJ ;
ALVAREZCOQUE, MCG .
JOURNAL OF LIQUID CHROMATOGRAPHY, 1995, 18 (14) :2827-2841
[6]   Quantitative retention-structure and retention-activity relationships of barbiturates by micellar liquid chromatography [J].
Cuenca-Benito, M ;
Sagrado, S ;
Villanueva-Camañas, RM ;
Medina-Hernández, MJ .
JOURNAL OF CHROMATOGRAPHY A, 1998, 814 (1-2) :121-132
[7]   Analysis of pharmaceutical preparations containing local anesthetics by micellar liquid chromatography and spectrophotometric detection [J].
Escuder-Gilabert, L ;
Sagrado, S ;
Villanueva-Camañas, RM ;
Medina-Hernandez, MJ .
CHROMATOGRAPHIA, 1999, 49 (1-2) :85-90
[8]  
ESCUDERGILABERT L, 2002, IN PRESS CHROMATOGRA, V55
[9]   Determination of active ingredients in cough-cold preparations by micellar liquid chromatography [J].
Gil-Agustí, M ;
Monferrer-Pons, L ;
García-Alvarez-Coque, MC ;
Esteve-Romero, J .
TALANTA, 2001, 54 (04) :621-630
[10]   Analysis of tricyclic antidepressants using electrogenerated chemiluminescence [J].
Greenway, GM ;
Dolman, SJL .
ANALYST, 1999, 124 (05) :759-762