Neutrophil Extracellular Traps Formation and Aggregation Orchestrate Induction and Resolution of Sterile Crystal-Mediated Inflammation

被引：45

作者：

Li, Yanhong ^{[1
]}

Cao, Xue ^{[1
]}

Liu, Yi ^{[1
]}

Zhao, Yi ^{[1
,2
]}

Herrmann, Martin ^{[2
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Rheumatol & Immunol, Chengdu, Sichuan, Peoples R China

[2] Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Internal Med Rheumatol & Immunol 3, Erlangen, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

sterile crystal; inflammation; neutrophil; neutrophil extracellular traps; aggregated neutrophil extracellular traps; ATHEROSCLEROTIC LESIONS; CALCIUM PYROPHOSPHATE; NLRP3; INFLAMMASOME; NADPH OXIDASE; GOUT; RECRUITMENT; ACTIVATION; RELEASE; MYELOPEROXIDASE; ATHEROGENESIS;

D O I：

10.3389/fimmu.2018.01559

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The formation of neutrophil extracellular traps (NETs) to immobilize pathogens represents a novel antimicrobial strategy of the immune system. The microcrystals related to human diseases are classified into endogenous microcrystals, including monosodium urate (MSU), calcium pyrophosphate dihydrate, calcium carbonate, calcium phosphate, calcium oxalate, cholesterol, and exogenous material like crystals from silica. Although microcrystals possess distinct compositions and shapes, they have a common characteristic: they stimulate neutrophils to release NETs. In low and high densities, neutrophils form NETs and aggregated NETs (aggNETs) that reportedly orchestrate the initiation and resolution of sterile crystal-mediated inflammation, respectively. Here, we summarize the different roles of NETs and aggNETs stimulated by the crystals mentioned above in related inflammatory reactions. The NETosis-derived products may represent a potential therapeutic target in crystal-mediated diseases.

引用

页数：6

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